Description
Release form
Drops for oral administration
Packing
Bottle of 10 ml.
Pharmacological action
Aquadetrim – Vitamin D3 – regulator of calcium-phosphorus metabolism. It is an active antirachitic factor. The most important function of vitamin D3 is to regulate the metabolism of calcium and phosphates, which contributes to the proper mineralization and growth of the skeleton.
Vitamin D3 is a natural form of vitamin D that is formed in humans in the skin by exposure to sunlight. Compared with vitamin D2, it is characterized by 25% higher activity. Colecalciferol plays a significant role in the absorption of calcium and phosphate from the intestine, in the transport of mineral salts and in the process of calcification of gum, and also regulates the excretion of calcium and phosphate by the kidneys. The concentration of calcium ions in the blood determines the maintenance of muscle tone of skeletal muscles, myocardial function, promotes nervous excitation, and regulates the blood coagulation process. Vitamin D is necessary for the normal function of the parathyroid glands, and is also involved in the functioning of the immune system, affecting the production of lymphokines.
Vitamin D deficiency in food, malabsorption, calcium deficiency, as well as insufficient exposure to sunlight, during the period of intensive growth of the child, leads to rickets, in adults, osteomalacia in pregnant women may cause symptoms of tetany, violation of the processes of calydification of bone tissue of newborns. An increased need for vitamin D occurs in women during menopause, as they often develop osteoporosis, due to hormonal disorders.
Indications
Prevention and treatment of vitamin D. deficiency
Prevention and treatment of rickets, rickets-like diseases, hypocalcemic tetany, osteomalacia and metabolic bone diseases (such as hypoparathyroidism and pseudohypoparathyroidism).
In the complex treatment of osteoporosis, including postmenopausal.
Contraindications
Hypersensitivity to the components of the drug, especially gasoline alcohol. Hypervitaminosis D, an increased concentration of calcium in the blood (hypercalcemia), increased excretion of calcium in the urine (hypercalciuria), urolithiasis (the formation of calcium oxalate stones), sarcoidosis, acute and chronic diseases of the liver and kidneys, renal failure, an active form of pulmonary tuberculosis. Children’s age up to 4 weeks of life.
Precautions: state of immobilization, when taking thiazides, cardiac glycosides (especially digitalis glycosides) during pregnancy and breastfeeding.
In infants with a predisposition to the early overgrowth of fontanelles (when small sizes of the anterior temples are established from birth).
Use during pregnancy and lactation
During pregnancy, Aquadetrim should not be used in high doses because of the possibility of a teratogenic effect in case of an overdose.
With caution, Aquadetrim should be prescribed in women breast-feeding a baby – a drug taken in high doses by the mother can cause symptoms of an overdose in the baby.
During pregnancy and breastfeeding, the dose of vitamin D3 should not exceed 600 IU per day
Special instructions
Avoid overdosing.
Individual provision for a specific need should consider all possible sources of this vitamin.
Too high doses of Aquadetrim, used continuously or in shock doses, may cause chronic hypervitaminosis D3.
Determination of a child ² ¢s daily requirement for vitamin D and the method of its use should be determined individually by a doctor and each time subjected to correction during periodic examinations, especially in the first months of life.
Do not use high doses of calcium simultaneously with aquadetrim.
During treatment, periodic monitoring of the concentration of calcium and phosphates in the blood and urine is necessary.
Composition of
1 ml of solution (30 drops) contains Colecalciferol (Vitamin D3) – 15,000 IU
Excipients: macrogol glyceryl ricinoleate, sucrose, sodium hydrogen phosphate dodecahydrate, citric acid monohydrate, aniseed aromatic water, anise alcohol, peeled.
Dosage and Administration
Orally.
Aquadetrim dissolved in 1 tablespoon of liquid.
1 drop contains about 500 IU of vitamin D3.
Unless otherwise prescribed by the doctor, the drug is used in the following dosages:
Prophylactic doses:
full-term newborns from 4 weeks of life, up to 2-3 years with proper care and sufficient exposure to fresh air: 500-1000 ME (1 drop) in
day premature babies, from 4 weeks of life, twins, babies in poor living conditions: 1000-1500 (2-3 drops) per day. In the summer, you can limit the dose to 500 ME (1 drop) per day.
pregnant women: a daily dose of 500 IU of vitamin D3 for the entire period of pregnancy, or 1000 IU / day, starting from the 28th week of pregnancy.
in the postmenopausal period 500-1000 ME (1-2 drops) per day.
Therapeutic doses:
for rickets: daily 2000 – 5000 ME (4-10 drops), depending on the severity of rickets (I, II or III) and course, for 4-6 weeks, under close monitoring of the clinical condition and the study of biochemical parameters (calcium, phosphorus, alkaline phosphatase) of blood and urine. Begin with 2000 ME for 3-5 days. Then, with good tolerance, the dose is increased to an individual therapeutic dose (most often 3000 ME). A dose of 5000 ME is prescribed only for severe bone changes.
If necessary, after one week break, you can repeat the course of treatment.
Treatment is carried out until a clear therapeutic effect is obtained, followed by a transition to a prophylactic dose of 500 – 1,500 IU / day.
in the treatment of rickets-like diseases: 20000-30000 ME per day (40-60 drops) depending on the age, body weight and severity of the disease, under the control of blood biochemical parameters and urinalysis. The course of treatment is 4-6 weeks. Treatment is carried out under the supervision of a physician.
in the complex treatment of postmenopausal osteoporosis: 500-1000 ME (1-2 drops) per day.
Dosage is usually given based on the amount of vitamin D that comes with food.
Side effects
Hypersensitivity to the drug, hypervitaminosis D (symptoms of hypervitaminosis: loss of appetite, nausea, vomiting headaches, muscle and joint pain, constipation, dry mouth, polyuria, mental weakness, including depression, weight loss, sleep disturbance, fever protein, leukocytes, hyaline cylinders appear in the urine, an increase in the level of calcium in the blood and its excretion in the urine is possible calcification of the kidneys, blood vessels, lungs).
When signs of hypervitaminosis D appear, the drug must be discontinued, calcium intake limited, vitamins A, C and B prescribed.
Drug Interactions
Antiepileptic drugs, rifampicin, cholestyramine reduce reabsorption of vitamin D3.
Concomitant use with thiazide diuretics increases the risk of hypercalcemia.
Concomitant use with cardiac glycosides can enhance their toxic effect (increased risk of heart rhythm disturbances).
Overdose
Symptoms: decreased appetite, nausea, vomiting, constipation, anxiety, thirst, polyurea, diarrhea, intestinal colic. Common symptoms include headache, muscular and joint pain, mental disorders, including depression, stupor, ataxia and progressive weight loss. Renal dysfunction with albinuria, erythrocyturia and polyuria, increased loss of potassium, hypostenuria, nocturia, and increased blood pressure develops.
In severe cases, a corneal opacification may occur, less than a papilla swelling, inflammation of the iris up to cataract development.
Kidney stones can form, the process of calcification of soft tissues, including blood vessels, heart, lungs and skin, occurs.
Cholestatic jaundice rarely develops.
Treatment:
Discontinue use of Akvadetrim. See your doctor. Take plenty of fluids. Hospitalization may be required if necessary.
Storage Conditions
Store at 5 ° C to 25 ° C. Protect from light. Keep out of the reach and sight of children.
Shelf life
3 years.
Deystvuyushtee substance
Kolekalytsiferol
Terms of drugstore
Without prescription
Dosage form
drops for pr Ime inside
