Description
Pharmacological action
Marfloxin 2% solution for injection belongs to the antibacterial drugs of the fluoroquinolone group.
The drug has a wide spectrum of bactericidal action, based on the suppression of bacterial enzymes of DNA gyrase and topoisomerase IV involved in the replication of DNA of microorganisms.
Marbofloxacin, the active substance of Marfloxin 2% solution for injection, is active against gram-positive and gram-negative microorganisms, including Escherichia coli, Salmonella typhimurium, Citrobacter freundii, Enterobacter cloacae, Serratia marcescens, Morganella morganii, Proteus spp, Klebsiella spp, Shigella spp, Pasteurella spp, Haemophilus spp, Moraxella spp, Pseudomiocococas spp, Pseudomrucomocasppp .
After intramuscular and subcutaneous administration of the drug at a dose of 2 mg / kg, marbofloxacin is well absorbed from the injection site and penetrates into most organs and tissues of the body. The bioavailability of marbofloxacin is more than 80%. The maximum concentration of marbofloxacin, about 0.5 Ñg / ml in piglets and 1 Ñg / ml in calves, in plasma is reached after 0.5-1.5 hours. The maximum plasma concentration of marbofloxacin in dogs and cats with subcutaneous administration of the drug is 1.5 Ñg / ml with 2 mg / kg and 3 Ñg / ml with 4 mg / kg. Marbofloxacin weakly binds to plasma proteins: in pigs, dogs and cats – by 10%, in cattle – by 30%. The concentration of marbofloxacin in organs is higher than the concentration in blood plasma. The half-life in calves is 5 ² 9 hours, in cattle with cicatricial digestion, 4 ² 7 hours, in pigs, 8 ² 10 hours, and in dogs and cats, 13 hours. Marbofloxacin is excreted from the body of animals mainly unchanged with urine and feces.
Marfloxin 2% injection for the degree of exposure to the body refers to low-hazard substances (hazard class 4 according to GOST 12.1.007-76).
Indications
Assign for the treatment of pigs and young cattle with respiratory diseases, pigs with MMA, and other diseases caused by strains of microorganisms sensitive to marbofloxacin. The drug is used to treat infected wounds, abscesses, prevention of wound infections during surgery in dogs and cats, with infections of the urinary system in dogs.
Contraindications
Increased individual sensitivity to the components of the drug.
Marfloxin 2% solution for injection is not recommended for animals with lesions of the central nervous system and in the case of resistance of the pathogen to other fluoroquinolones, as well as puppies of large dog breeds up to 18 months of age, the rest of the dog breeds to 12 months of age.
Recommendations for use
The drug is used in animals once a day, in calves subcutaneously, intramuscularly or intravenously, pigs – intramuscularly, in a daily dose of 2 mg / kg of animal weight according to the active substance (is 1 ml of the drug per 10 kg). For the treatment of wound infections and abscesses in dogs, the drug is administered subcutaneously once at a dose of 2 mg / kg (1 ml of the drug per 10 kg of animal weight), further treatment is continued using Marfloxin tablets. In the treatment of infections of the urinary system in dogs, a dose of 4 mg / kg (2 ml of the drug per 10 kg of the animal s weight) is administered subcutaneously once a day. The drug is administered three times with an interval of 4 days. For the prevention of wound infections and abscesses during surgical procedures in dogs and cats, the drug is administered at a dose of 2 mg / kg intravenously once immediately after surgery.
For the treatment of wound infections and abscesses in cats, the drug is administered subcutaneously once a day at a dose of 2 mg / kg (0, 5 ml of the drug per 5 kg of animal weight). Duration of administration is from 3 to 5 days.
The duration of treatment for young cattle and pigs is 3 to 5 days.
In case of overdose in animals, disturbances in the activity of the nervous system can be observed. The treatment is symptomatic. Cats and dogs may experience symptoms of bradycardia.
Peculiarities of the action of the drug during its first use and withdrawal have not been identified.
Studies in laboratory animals (rats and rabbits) did not reveal teratogenic and embryotoxic effects, as well as the negative effects of marbofloxacin on reproductive function in female animals. The drug can be used by pregnant and lactating sows. The ability to use Marfloxin 2% solution for injection during pregnancy and lactation in dogs and cats is determined by the veterinarian based on an assessment of the ratio of the expected benefit to the possible risk of using the drug.
Avoid skipping the next dose of the drug, as this can lead to a decrease in therapeutic efficacy. In case of missing one dose of the drug is resumed in the same dosage and in the same way.
Special instructions
It is not recommended to use Marfloxin 2% solution for injection simultaneously with chloramphenicol, macrolide antibiotics and tetracycline.
Slaughter of cattle for meat is allowed no earlier than 4 days after repeated administration of the drug at a dose of 2 mg / kg and 5 days after a single administration of the drug at a dose of 8 mg / kg, pigs – 3 days after the last use of the drug. Meat of animals forced to be killed before the expiration of the specified period can be used as feed for fur animals.
Personal preventive measures
When working with Marfloxin 2% solution for injection, you must follow the general rules of personal hygiene and safety precautions provided for when working with medicines.
People with hypersensitivity to fluoroquinolones should avoid direct contact with the drug. It is forbidden to use empty packaging from the preparation for domestic purposes, it must be disposed of with household waste.
In case of accidental contact with the skin or mucous membranes, wash it off immediately with running water and soap. In case of allergic reactions and / or in case of accidental ingestion of a drug into the human body, you should immediately contact a medical institution (you should have the instructions for use of the drug or a label with you).
Composition
Marfloxin 2% injection contains 20 mg of marbofloxacin as active ingredient and 16 mg of gluconolactone as excipients, edetate disodium 0.10 mg, 30 mg mannitol, 2 mg metacresol, 0.5 mg monotioglycer mg, water for injection up to 1.0 ml.
Side effects
When using the drug at the recommended dose, no side effects were found in pigs and cattle. An inflammatory reaction may occur at the injection site. In case of allergic reactions, the use of the drug is stopped and antihistamines are prescribed to the animal, if necessary, symptomatic treatment is carried out.
Storage conditions
In the manufacturer s sealed packaging, in a dry place, protected from direct sunlight and inaccessible to children and animals, separately from food and feed at a temperature of 5 ° C to 25 ° C. Do not freeze!
Shelf life
3 years from the date of manufacture. After opening the bottle, the drug can be used within 28 days.
Active ingredient
Marbofloxacin
Dosage form
injection solution
