Description
Latin name
Rozamet
Release form
Cream for external use 1% white, homogeneous, odorless.
Packaging
25 g – aluminum tubes (1) – packs of cardboard.
Pharmacological action of
When applied topically, it has an anti-acne effect whose mechanism is not exactly known (not related to the effect on the Demodex folliculorum tick found in hair follicles and sebaceous secretions, and any effect on the production of this secretion). Metronidazole for external use may have antioxidant activity.
It has been found that it significantly reduces the production of neutrophils of active oxygen, hydroxyl radicals and hydrogen peroxide, which are potential oxidants, capable of causing tissue damage at the site of inflammation. Metronidazole for external use is ineffective against telangiectasias observed with rosacea.
Pharmacokinetics
When applied topically, the drug is practically not absorbed.
Indications
inflamed papules, pustules of erythema
with rosacea and acne vulgaris (acne rozacea, acne vulgaris)
balanoposthitis
vulvovaginitis.
Contraindications
Hypersensitivity.
Precautions: pregnancy (I trimester), lactation.
Use during pregnancy and lactation
Precautions: pregnancy (I trimester), lactation.
Composition
1 g
metronidazole 10 mg
Excipients: glycerol – 12.9 mg, liquid paraffin – 90 mg, emulsifying wax – 100 mg, propylene glycol – 20 mg, methyl parahydroxybenzoate – 0.7 mg, propyl parahydroxybenzoate 0.3 mg, 7 mg water – 7 mg .
Dosage and Administration
Externally.
Treatment of inflamed papules, pustules, erythema with rosacea and acne vulgaris (acne rozacea, acne vulgaris): apply a thin layer to the skin previously cleaned with warm water or a light detergent and rub 1-2 times a day, morning and evening. The course of treatment is 1-2 months. Between cleansing the skin and applying the cream, it is recommended to take a break of 15-20 minutes. The therapeutic effect occurs after about 3 weeks. The average duration of treatment is 3-4 months.
Balanoposthitis, vulvovaginitis: a small amount of cream is applied to the surface of the lesions of the glans penis, foreskin, labia minora, vestibule with a cotton swab or fingers, rubbing lightly, or using an applicator (intravaginally) 1-2 times a day.
Duration of treatment – 8-10 days.
Side effects
Side effects after external use of metronidazole are extremely rare. Allergic reactions (urticaria, skin rash) hyperemia, peeling and burning of the skin, lacrimation are possible.
Storage Conditions
At a temperature not exceeding 25 ° C.
Keep out of the reach and sight of children.
Shelf life
2 years.
Do not use after the expiration date printed on the package.
Terms and conditions
without prescription
Formulation
cream
Indications Indications
inflamed papules, erythema with acne vulgaris, Vulvovaginitis, Balanoposthitis, Inflamed pustules, Erythema with rosacea
Jadran-Galenski Laboratories a.o., Croatia
