Description
Release form
Tablets
Packing
20 pcs.
Pharmacological action
Macmirror – antimicrobial, antiprotozoal, antifungal.
Pharmacodynamics
Nifuratel, an antimicrobial agent from the group of nitrofurans, has an antiprotozoal, antifungal and antibacterial effect.
Nifuratel has high efficiency and low toxicity, which leads to a wide range of its clinical applications.
Highly effective against Papiliobacter and Helicobacter pylori, gram-positive and gram-negative microorganisms: at a minimum inhibitory concentration (MIC) of 12.5 25 μg / ml inhibits from 44.3 to 93.2% of the cultures.
It is highly active against both aerobic and anaerobic pathogens.
The spectrum of action includes: Enterococcus faecalis, Enterococcus faecium, Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Shigella flexneri 2a, Shigella flexneri 6, Shigella sonnei, Salmonella typhi, Salmonella typhid, Salmonella spp. ., Citrobacter spp., Morganella spp., Rettgerella spp., Pragia fontium, Budvicia aquatica, Rachnella aquatilis and Acinetobacter spp., Other atypical enterobacteria, as well as protozoa (amoeba, giardia) less active against Proteus mirabgar, Proteud vulse aeruginosa.
Is the drug of choice for the treatment of salmonellosis, shigellosis and other intestinal bacterial infections.
Active against Trichomonas vaginalis, highly active against fungi of the genus Candida.
Particularly effective against metronidazole resistant Helicobacter pylori strains.
Data showing high activity of nifuratel (in vitro and in vivo) against Atopobium vaginae, the main marker of bacterial vaginosis, has been obtained.
Pharmacokinetics
When administered orally, it is rapidly absorbed from the digestive tract. Penetrates through the BBB and the hematoplacental barrier, excreted in breast milk. Metabolized in the liver and muscle tissue. It is completely excreted from the body by the kidneys (30-50% – unchanged), having a strong antibacterial effect in the urinary tract.
Contraindications
Hypersensitivity. With caution – pregnancy, lactation.
Use during pregnancy and lactation
Nifuratel crosses the hematoplacental barrier after an overdose, therefore, the use of the drug is possible only under strict indications, if the expected effect of therapy exceeds the potential risk to the fetus.
Nifuratel is excreted in breast milk, so if you need to prescribe the drug during lactation, you should decide whether to stop breastfeeding.
Special instructions
When monotherapy of vaginal infections with Macmiror is recommended, it is recommended to increase the daily dosage to 4-6 tablets. During treatment should refrain from sexual intercourse.
Influence on the ability to drive a car or other mechanisms: no adverse effects were detected.
Composition
1 tablet contains:
Active substance: nifuratel 200 mg.
Auxiliary Ingredients: starch polyethylene glycol 6000 talc magnesium stearate gelatine gum arabic sucrose magnesium carbonate titanium dioxide E wax.
Side effects
Dyspeptic disorders: nausea, vomiting, bitterness in the mouth, diarrhea, heartburn, gastralgia.
Allergic reactions: skin rash, itching.
Drug Interactions
Enhances the antifungal effect of nystatin.
Storage conditions
In a dry place, at a temperature not exceeding 25 ° C
Expiration
2 years.
active substance
nifuratel
Terms leave through pharmacies
In retseptu
lekarstvennaja form
tablets
Prescription
Adults prescribed by a doctor, Children prescribed by a doctor
Indications
Indications
vaginitis, an inflammation of female genitals, vaginal candidiasis, from amebiasis and giardiasis
Doppely Farmatseutitsi, Italy
