Description
Latin name
Nystatin ointment
Release form
Ointment for external use
Pharmacological action
Nystatin is a polyene antifungal antibiotic that is highly active against yeast-like fungi of the genus Candida. It has a fungicidal effect. In the structure of the antibiotic, there are a large number of double bonds with high tropism for sterol structures of the cytoplasmic membrane of fungi, which contributes to the incorporation of the drug molecule into the cell membrane and the formation of a large number of channels through which uncontrolled transport of electrolytes occurs. An increase in osmolarity inside the cell leads to its death.
Contraindications
Hypersensitivity, impaired liver function, pancreatitis, peptic ulcer of the stomach and duodenum, pregnancy.
Composition
Active ingredient: nystatin 100000 IU
Excipients: lanolin anhydrous petroleum jelly.
Dosage and administration
Locally, apply the ointment in a thin layer to the affected areas of the skin and mucous membranes 1-2 times per day, daily for 7-10 days. Can be combined with oral administration.
Side effects
Nausea, vomiting, diarrhea, sometimes fever, chills. There is a risk of the spread of resistant forms of fungi (requires discontinuation of the drug).
Drug interaction
With the simultaneous use of nystatin with clotrimazole, the activity of the latter decreases.
Storage conditions
In a dry, dark place, at a temperature not exceeding 5 ° C.
Term hodnosty
3 years
Deystvuyuschee substances
nystatin
Pharmacy terms
Prescription
Dosage form
ointment
