Description
Enteric-release form enteric-coated tablets
Packing
60 pcs.
Pharmacological action
Digestive enzyme, compensates for the insufficiency of the secretory function of the pancreas and biliary function of the liver, improves digestion of food, has a proteolytic, amylolytic and lipolytic effect.
Pancreatic enzymes (lipase, alpha-amylase, trypsin, chymotrypsin) that break down proteins help break down proteins to amino acids, fats to glycerol and fatty acids, and starch to dextrins and monosaccharides.
Trypsin suppresses stimulated pancreatic secretion by providing an analgesic effect.
The enzyme hemicellulase promotes the breakdown of plant fiber, which also improves digestive processes, reduces the formation of gases in the intestines. Bile extract acts choleretic, promotes emulsification of fats, improves absorption of fats and fat-soluble vitamins, increases lipase activity.
, unusual or indigestible food, with nervousness, etc.), intestinal infections, chronic diseases in the liver and biliary tract, intestinal degassing before agnostic studies (mammography, ultrasound and others.).
Contraindications
Hypersensitivity (including pork intolerance), acute pancreatitis, exacerbation of chronic pancreatitis.
Special instructions
The safety of pancreatin during pregnancy is not well understood.
Use is possible in cases where the expected benefit to the mother outweighs the potential risk to the fetus.
In cystic fibrosis, the use of pancreatin in high doses is not recommended due to an increased risk of developing strictures (fibrotic colonopathy). The dose should be adequate to the amount of enzymes necessary for the absorption of fats, taking into account the quality and quantity of food consumed.
Ingredients
Active ingredient:
pancreatin 250 mg
Excipients:
carboxymethyl starch sodium (primrose) 1,5 ml starch (1.5 g), starch – 16.5 mg, povidone (low molecular weight polyvinylpyrrolidone medical) – 5 mg, magnesium stearate – 3.3 mg, colloidal silicon dioxide (aerosil) – 3.3 mg, microcrystalline cellulose – to obtain a tablet without a shell weighing 330 mg.
Shell composition:
cellacephate (acetylphthalyl cellulose) – 2.847 mg, polysorbate (tween 80) – 0.85 mg, liquid paraffin (liquid paraffin) – 0.5 mg, brown iron oxide (sycamite 70 (E172), ferronate (E172)) – 0.803 mg .
Dosage and administration
Inside, swallowing whole (without chewing), during or immediately after a meal, with plenty of liquid (possibly alkaline: water, fruit juices). The dose of the drug is set individually (in terms of lipase) depends on the age and degree of pancreatic insufficiency.
It is not recommended to exceed the maximum daily dose of enzymes of 15,000-20,000 units of lipase / kg, especially in patients with cystic fibrosis.
The average dose for adults is 150 thousand units / day with complete insufficiency of exocrine pancreatic function – 400 thousand units / day, which corresponds to the daily needs of an adult in lipase.
The duration of treatment can vary from a single dose or several days (if the digestive process is disturbed due to errors in the diet) to several months or even years (if constant replacement therapy is necessary). Adults – 3-4 tablets 3 times a day. Higher doses are prescribed by a doctor. 2 tablets 2-3 times a day for 2-3 days before x-ray or ultrasound examination.
For children over 3 years old – 100 thousand units / day (for lipase), divided into 3-4 doses.
Side effects
Symptoms of intestinal obstruction (strictures in the ileocecal and ascending colon) and immediate allergic reactions (with cystic fibrosis, especially in children).
Drug interaction
With the simultaneous use of pancreatin with iron preparations, a decrease in absorption of the latter is possible. The simultaneous use of antacids containing calcium carbonate and / or magnesium hydroxide can lead to a decrease in the effectiveness of pancreatin.
Overdose
Symptoms: With prolonged use in high doses – hyperuricosuria. when using high doses in patients with cystic fibrosis – strictures in the ileocecal section and in the ascending colon. Hyperuricemia Children have constipation.
Treatment: drug withdrawal, symptomatic therapy.
Storage conditions
Store in a dry place, at a temperature not exceeding 20 ° C. Keep out of reach of children.
Do not use after the expiration date.
Term hodnosty
2 years
active substance
Pancreatin
Prescription conditions from
pharmacies Without prescription
lekarstvennaja form
tablets
