Description
Latin name
Papaverine
Packing
10 pcs
Pharmacological action
Papaverine is a myotropic antispasmodic.
Pharmacokinetics
Bioavailability of papaverine after rectal administration (according to preclinical studies) is about 25%. Communication with plasma proteins 90%. It is well distributed, penetrates histohematological barriers. Metabolized in the liver. The half-life (T1 / 2) is 0.5-2 hours (an increase of up to 24 hours is possible). It is excreted by the kidneys in the form of metabolites.
Indications
Spasm of smooth muscles: abdominal organs (with cholecystitis, pylorospasm, spastic colitis) with renal colic of peripheral vessels (with endarteritis) of the cerebral vessels (with migraine) of the heart (with angina pectoris as part of complex therapy) bronchial bronchi ( )
Contraindications
Hypersensitivity to the drug, atrioventricular block, glaucoma, severe liver failure, old age (risk of hyperthermia), childhood, because the dosage regimen for children is not indicated.
With caution
Use with caution and in small doses in the condition after traumatic brain injury, chronic renal failure, adrenal insufficiency, hypothyroidism, prostatic hyperplasia, supraventricular tachycardia, shock conditions.
Use during pregnancy and lactation
During pregnancy and during lactation (breastfeeding), the safety and effectiveness of papaverine has not been established.
Composition
Composition per suppository: active ingredient: papaverine hydrochloride – 20 mg excipients: solid fat (Vitepsol (brands H 15, W 35), Supposir (brands NA 15, NAS 50)) – until a suppository weighs 1, 25 g.
Dosage and administration
Rectally. Having released the suppository from the contour packaging, it is introduced into the anus. Apply 1 suppository 2 to 3 times a day after spontaneous bowel movements or cleansing enemas.
Side effects
Allergic reactions, atrioventricular block, ventricular extrasystole, increased activity of hepatic transaminases, decreased blood pressure, drowsiness, constipation, eosinophilia are possible.
Drug Interaction
Reduces the effect of dopegite.
Efficiency decreases when smoking.
Storage Conditions
Store in a dark place.
Shelf life
2 years. Do not use the drug after the expiration date indicated on the package.
Deystvuyushtee substance
papaverine
Terms and conditions
without prescription
Dosage form a
rectal suppositories
Appointment
Appointment
Adult
