Description
Form release
tablets
Packing
per pack 50 pcs.
Pharmacological action
Pyrazidol – timoleptic, antidepressant.
Selectively inhibits MAO type A, blocks the deamination of serotonin and norepinephrine, to a lesser extent tyramine. Partially inhibits monoamine reuptake, potentiates the effects of norepinephrine precursor – dioxiphenylalanine (L-dopa) and serotonin precursor – 5-hydroxytryptophan. Stimulates adrenergic and serotonergic structures. Activates the processes of synaptic transmission of nervous excitation in the central nervous system. It has a nootropic effect, improves cognitive function.
Pharmacodynamics
The timoleptic effect is combined with a balanced effect on the central nervous system (activating effect in patients with apathetic, anergic depressions or sedative effect in patients in an agitated state).
Indications
Depression, incl. senile, involutional, occurring mainly with psychomotor inhibition and asthenic disorders, anxiety-depressive or anxiety-delusional components, alcohol withdrawal syndrome, Alzheimer’s disease (as part of complex therapy).
Contraindications
Hypersensitivity, acute hepatitis, blood diseases, concomitant use of MAO inhibitors.
Use during pregnancy and lactation
Adequate and strictly controlled studies on the safety and effectiveness of the drug during pregnancy and lactation have not been conducted.
Special instructions
Pyrazidol is not prescribed simultaneously with MAO inhibitor antidepressants, furazolidone, procarbazine, selegiline.
Pirazidol may be used in patients with glaucoma and benign prostatic hyperplasia.
Pyrazidolum is compatible with antipsychotic agents, anxiolytics.
Composition
Active ingredient: pirlindol
Excipients: sugar milk starch potato calcium stearate
Dosage and administration
Inside, at 0.05-0.075 g / day in 2 divided doses, gradually increasing the dose by 0.025-0.05 g to 0.15-0.30 g / day. The maximum daily dose is 0.4 g, divided into 2-3 doses. After the therapeutic effect is achieved, treatment is continued for 2 4 weeks, after which the dose is gradually reduced.
Side effects
Dry mouth, nausea, sweating, hand tremor, tachycardia, dizziness, allergic reactions.
Drug Interactions
Increases the effectiveness of epinephrine (due to antimonoamine oxidase activity). Compatible with antipsychotic drugs, anxiolytics. Incompatible with antidepressants – MAO inhibitors, furazolidone, procarbazine, selegiline.
Storage conditions
In a dry, dark place, at a temperature not exceeding 25 ° C.
Term hodnosty
3 years
active substance
Pirlindol
lekarstvennaja form
tablets
Pharmstandard-Leksredstva, Russia
