Description
Release form
Cream for external use.
Pharmacological action
Pharmacodynamics
Nonivamide is a synthetic analogue of capsaicin and has analgesic properties which are manifested as a result of the gradual penetration of the active substance into peripheral nociceptive C-fibers and A-delta nerve fibers upon repeated application of the drug to the skin.
Nonivamide has a vasodilating effect, which is accompanied by an intense, prolonged sensation of warmth, due to the stimulation of afferent nerve endings in the skin. Nicoboxyl is a derivative of nicotinic acid with vasodilating properties with the participation of prostaglandins I2 and E2. The hyperemic effect of nicoboxyl (butoxyethyl ester of nicotinic acid) develops faster and has a greater intensity than the hyperemic effect of nonivamide.
Combined action of
Nonivamide and nicoboxyl have complementary vasodilating properties, cause skin hyperemia, increase the rate of enzymatic reactions, activate metabolism.
The appearance of hyperemia and an increase in skin temperature within a few minutes after application indicate the rapid penetration of the active components of the drug into the skin.
The action of Finalgon manifests itself locally, develops in a few minutes and reaches a maximum in 20-30 minutes.
Pharmacokinetics
Pharmacokinetics of Finalgon ® not available.
Indications
Arthritis
arthralgia and myalgia of a rheumatic genesis
sports injuries, bruises and injuries of the ligamentous apparatus
myalgia caused by excessive physical stress
lumbago
neuritis muscle training the composition of complex vasodilator therapy for peripheral circulation disorders.
Contraindications
Hypersensitivity to
nicoboxyl, nonivamide or excipients in children under 12 years of age.
preparation should not be applied to sensitive skin, open wounds, inflamed skin areas, areas of skin with increased permeability: neck, lower abdomen, inner thighs.
Use during pregnancy and lactation
Since clinical experience with the drug during pregnancy and lactation is insufficient, it is not recommended to prescribe Finalgon ® in this category of patients.
It is not known whether the active ingredients in Finalgon are excreted in breast milk.
Special instructions
The drug causes flushing of the skin, resulting in redness, a feeling of warmth, itching and burning in the place of use. These symptoms may be more pronounced when applying an excessive amount of the drug or in the case of intense rubbing on the surface of the skin. Using excessive amounts of the drug or intensive rubbing on the surface of the skin can lead to the appearance of vesicles or pustules at the site of application of the ointment.
After using Finalgon ®, wash your hands immediately with soap.
Care must be taken to avoid accidentally getting the drug on other areas of the skin or getting the drug on another person.
Avoid accidental contact with the drug on the face, eyes, nose, or mouth. This can lead to temporary swelling of the face, pain in the face, conjunctival inflammation, flushing of the eyes, burning eyes, blurred vision, discomfort in the oral cavity and stomatitis.
Before or after applying the drug to the skin, do not take a hot bath or shower.
The release of sweat or the application of heat to the place of application of the drug can cause redness of the skin and an intense sensation of warmth even several hours after the application of Finalgon.
The preparation contains sorbic acid, which can cause local skin irritation (for example, contact dermatitis).
Effect on the ability to drive vehicles and other mechanisms that require an increased concentration of attention
There have been no special clinical studies of the effect of the drug on the ability to drive a car and mechanisms. However, caution should be exercised during the use of the drug when driving and working with mechanisms.
Composition
1 g
nonivamide 1.7 mg
nicoboxyl 10.8 mg
Excipients: decyl oleate – 50 mg, emulsifier F – 10 mg, macrogol cetostearyl ether – 30 mg, stearic acid – 20 mg – 2 liquid paraffin – 30 mg, sorbic acid – 2 mg, perfume vegetable oil – 2 mg, purified water – 823.5 mg.
Dosage and Administration
Treatment should be started by applying a small amount of the drug to a small area of ??the skin to evaluate an individual reaction. The individual reaction to the drug can vary significantly: for some people it will be enough to apply a small amount of ointment, in order to cause the necessary warming effect.
Using the attached applicator, a column of the drug no larger than 0.5 cm in size is applied to the corresponding area of ??the skin the size of a palm with light rubbing movements. To enhance the therapeutic effect, the skin area on which the preparation is applied can be covered with woolen cloth.
With repeated use, the reaction to the ointment may decrease, which requires an increase in the dose, which is selected individually.
If necessary, use the cream 2-3 times / day.
To preheat muscles before exercise, sports, it is recommended to rub about 30 minutes before they start.
The patient should be warned that if there is no desired effect within 10 days, consult a doctor.
After applying the drug to the skin, wash your hands thoroughly with soap and water.
Side effects of
During the long experience of using the drug, the following side effects were identified:
From the immune system: anaphylactic reactions, hypersensitivity.
From the nervous system: paresthesia, burning sensation of the skin.
From the respiratory system: cough, shortness of breath.
From the skin and subcutaneous tissues: vesicles or pustules at the site of application, local skin reaction (eg contact dermatitis), itching, rash, facial swelling, urticaria, sensation of heat at the site of application.
Drug interaction
Drug interaction of the drug Finalgon ® with other drugs used topically or systemically has not been identified.
Overdose
Symptoms: The effect of hyperemia of the skin and the severity of dose-dependent side effects may worsen after applying an excessive amount of Finalgon ® ointment. The use of excessive amounts of the drug can lead to the appearance of vesicles or pustules at the site of application of the ointment.
An overdose of the drug can cause systemic reactions (redness of the upper body, fever, flushing, painful hyperemia, decreased blood pressure), because nicotinic acid esters have good transdermal absorption.
Treatment: when using an excessive amount of the drug, the effect may be reduced, if you remove the ointment from the surface of the skin with vegetable oil or cosmetic cream on a greasy basis, from the mucous membrane of the eye (in case of accidental contact) – with the help of medical vaseline. If necessary, symptomatic treatment should be given.
Storage conditions
Keep out of the reach and sight of children at temperatures not exceeding 25 ° C.
Active ingredient
Nicoboxyl, Nonyvamyd
holidays Terms
without prescription
