Description
Pharmacological action
Combined anthelmintic drug. It has a wide range of nematicidal and cestocidal effects on all phases of the development of round and ribbon helminths, parasitic in dogs and cats, including Toxocara canis, Toxocara cati, Toxascaris leonina, Uncinaria stenocephala, Ancylostoma caninum, Ancylostoma tubaeforme, Hydatigera taeniaeformis, Dipylidium caninum, Echinococcus granulosis, Echinococcus multilocularisinumipides, Dipylidocompidae, Dipylidium spp.
The mechanism of action of the active components included in the preparation is based on the inhibition of fumarate reductase, persistent depolarization of the helminth muscle cells, impaired energy metabolism, which causes paralysis and death of the parasite, contributes to its removal from the digestive tract.
Praziquantel acts on tapeworms (cestodes). Primarily, it causes muscle excitement, leading to spastic paralysis of the muscles of the parasite. This leads to vacuolization of the helminth cell membranes, which allows intestinal enzymes to act on the parasite, causing its death. When administered orally, praziquantel is rapidly absorbed in the intestine and distributed in organs and tissues, excreted mainly in the urine in a metabolized form.
Pyrantel is active against gastrointestinal nematodes. It is a neuromuscular ganglion blocker that causes persistent depolarization and spastic paralysis of roundworm muscles. Pyrantela embonate is partially absorbed in the intestine and excreted mainly with feces within 24-48 hours.
Pratel according to the degree of exposure to the body are low-hazard substances (hazard class 4 according to GOST 12.1.007-76) in the recommended doses do not have a sensitizing effect embryotoxic and teratogenic effects. Well tolerated by dogs and cats of different breeds and ages.
Indications
Treatment and prevention of helminthiases in dogs and cats, including: nematodoses (toxocariasis, toxascaridosis, uncinariosis, hookworm) of cestodoses (teniosis, dipylidiosis, echinococcosis, mesocestodosis).
Contraindications
Increased individual sensitivity to the components of the drug, including in the anamnesis. It is forbidden to use Pratel in the first half of pregnancy, severely malnourished, patients with infectious diseases and recovering animals. The use of the drug is not allowed for severe violations of the liver and kidneys, as well as puppies and kittens younger than 6 weeks of age.
Do not exceed or underestimate the recommended dose of Pratel.
Composition
1 tablet contains 144 mg of pyrantel embonate and 50 mg of praziquantel.
Dosage and administration
Tablets are given to dogs and cats once, individually in a crushed form with food or forcefully on the root of the tongue in the following doses: kittens and dogs weighing up to 2 kg – tablets,
to cats and dogs weighing from 2 to 5 kg – tablets,
for dogs weighing 5 to 10 kg – 1 tablet, for dogs weighing 10 to 20 kg – 2 tablets,
for dogs weighing 20 to 30 kg – 3 tablets, for dogs weighing 30 to 40 kg – 4 tablets,
for dogs weighing 40 to 50 kg – 5 tablets.
Pratel can be used for puppies and kittens from the age of 6 weeks.
A preliminary fasting diet and laxatives before deworming are not required.
For therapeutic purposes, the drug is used in animals once, for prophylactic purposes – once a quarter, as well as before vaccination and 2-4 weeks before the expected mating period in a therapeutic dose.
Pregnant females use the drug in the last third of pregnancy, lactating – 2-3 weeks after birth under the supervision of a veterinarian.
Peculiarities of the drug during its first use and withdrawal has not been established.
If you miss the next preventive deworming, it should be done as soon as possible in the same dose.
Side effects
When using the drug for indications and at recommended doses, side effects and complications, as a rule, are not observed.
With increased individual sensitivity of the animal to the components of the drug, allergic reactions are possible.
Overdose symptoms in dogs and cats have not been identified.
dosage form
tablets
