Description
Pharmacological action of
Heparin antagonist, forms stable complexes with heparin, while eliminating the ability of heparin to inhibit blood coagulation. Complexation is due to the abundance of cationic groups (due to arginine), which bind to the anionic centers of heparin. The action occurs instantly (on the needle). In case of an overdose, it may decrease blood coagulability, as It exhibits anticoagulant activity. The duration of the effect is 2 hours
Indications
Overdose of heparin (hyperheparinemia, bleeding) before surgery in patients who take heparin for therapeutic purposes after operations on the heart and blood vessels with extracorporeal circulation.
Contraindications
Idiopathic or congenital hyperheparinemia, severe hypotension, thrombocytopenia, adrenal insufficiency.
Recommended use
Intravenously injected slowly or drip under the control of blood coagulation.
In case of an overdose of heparin, a 1 ml solution is injected at a rate of 1 ml in 2 minutes. If necessary, the injections are repeated at intervals of 15-30 minutes, the total dose is usually 5 ml of a 1% solution.
The maximum dose is 150 mg / h.
In case of bleeding, the daily dose is 5-8 mg / kg iv administered in 2 divided doses with an interval of 6 hours.
Special instructions
In case of overdose, it may decrease blood coagulation, as itself has anticoagulant activity.
Composition
Active ingredient:
protamine sulfate (in terms of dry matter) – 10 mg
Excipients:
0.05 M solution of sulfuric acid – up to pH 4.0-6.0 water for injection – up to 1 ml.
Side effects
From the cardiovascular system: bradycardia, arterial hypotension.
From the digestive system: nausea, vomiting.
Allergic reactions: skin rash, itching.
Other: a sensation of heat, flushing of the skin, a feeling of lack of air (with excessively rapid administration).
active substance
Protamine sulfate
Dispensing conditions from
pharmacies Prescription
dosage form
suspension for injection
