Description
Pharmacological action
Dirofen-paste 20 refers to combined anthelmintic drugs. Thanks to praziquantel and pyrantel, which is part of the preparation, it has a wide spectrum of anthelmintic action on the mature and larval stages of development of round and ribbon helminths, which are parasitic in dogs and cats (Tohosara sannis, Tohosara mistax, Toxascaris leonina, Uncinaria stenocephala, Trichuris vulpis, Ancylostoma caninum, Echinococcus granulosus, Alveococcus multilocularis, Mesocestoides lineatus, Dipylidium caninum, Diphyllobotrium latum, Multiceps ichiocinidaexiocaris leoma tomica tomica (Syphacia obvelata, Syphacia muris, Aspiculuris tetraptera, Rodentolepis straminea, Hymenolepis nana, Hymenolepis diminuta).
The mechanism of action of the praziquantel and pyrantel pamoate included in the drug is based on the inhibition of fumarate reductase, persistent depolarization of the helminth muscle cells, impaired energy metabolism, which causes paralysis and death of helminths and helps to eliminate them from the gastrointestinal tract.
When administered orally, praziquantel is rapidly absorbed in the gastrointestinal tract, reaching a maximum plasma concentration after 1 to 3 hours, and is distributed in the animal’s organs and tissues, excreted mainly in the urine (up to 80%) within 24 hours. Pyrantel pamoate is poorly absorbed, which ensures its prolonged effect on helminths in the intestine, is excreted from the body mainly in unchanged form with feces (93%).
Dirofen-paste 20 by its degree of exposure to the body belongs to low-hazardous substances (hazard class 4 according to GOST 12.1.007-76), at the recommended doses it does not have embryotoxic, teratogenic and sensitizing effects. Well tolerated by dogs and cats of different breeds and ages, ferrets and rodents.
Recommendations for use
Dirofen-paste 20 is applied to animals individually, once, in the morning feeding with a small amount of feed, or force-fed to the root of the tongue using a syringe dispenser in the doses indicated in the table.
A preliminary fasting diet and laxatives are not required. With a strong degree of invasion, deworming is recommended to be repeated after 10 days.
For prophylactic purposes, deworming is carried out in a therapeutic dose once every 3 months, as well as before each vaccination.
Composition of
Pyrantel pamoate – 15 mg / ml, praziquantel – 5 mg / ml,
excipients up to 1 ml
active substance
pyrantel, praziquantel
