Description
Pharmacological action
Dirofen-paste and 60 belongs to the pharmacotherapeutic group: anthelmintic drugs in combinations.
The combination of the pyrantel and praziquantel pamoate preparations has a wide spectrum of anthelmintic action on all phases of the development of round and ribbon helminths, which are parasitic in dogs, cats, ferrets (Toxocara canis, Toxocara mystax, Toxascaris leonina, Taenomaomaenium anoma niumomaenium anoma nio menomaumiumium, Taenia malaria , Echinococcus granulosus, Alveococcus multilocularis, Mesocestoides lineatus, Dipylidium caninum, Diphyllobothrium latum, Multiceps multiceps) and in decorative rodents (Syphacia obvelata, Syphacia muris, Aspiculuris tetraptera, Rodent, Rodent Hymenolepis nana, Hymenolepis diminuta).
Pyrantela pamoate is a compound of the pyrimidine group, active against sexually and immature nematodes, its mechanism of action is based on the blockade of transmission of nerve impulses in the neuromuscular synapses by depolarization of the membranes of muscle cells, which causes paralysis of the muscular system of nematodes, the pyrantel is poorly absorbed, which ensures prolonged the effect on helminths in the intestine is excreted from the body mainly unchanged (93%) with feces.
Praziquantel is a compound of the pyrazinisoquinoline group, which is active against sexually mature and immature cestodes its mechanism of action is based on the induction of tegument breakdown and inhibition of fumarate reductase, persistent depolarization of helminth muscle cells, impaired energy metabolism, which causes paralysis and death of cestodes and contributes to their removal from the gastrointestinal tract. Praziquantel is rapidly absorbed in the gastrointestinal tract, reaching a maximum concentration in blood plasma after 1-3 hours, distributed in the organs and tissues of the animal, binds to serum blood proteins (70-80%), partially metabolized in the liver, re-secreted into the intestine, excreted from body mainly with urine (up to 80%).
Dirofen-paste 60, according to the degree of exposure to the body, belongs to low-hazard substances (hazard class 4 according to GOST 12.1.007-76), at the recommended doses it does not have embryotoxic, teratogenic and sensitizing effects. Well tolerated by dogs and cats of different breeds and ages, ferrets and rodents.
Indications
Dirofen paste 60 – for adult dogs and cats, with prophylactic and therapeutic purposes for nematodoses (toxocariasis, toxoscaridosis, uncinariosis, ankylostomiasis), cestodoses (teniidosis, dipyldiosis, echinococcosis, diochemosis, diochemosis),
Contraindications
Increased individual sensitivity to the components of the drug. It is not recommended to deworm females in the first half of pregnancy and within 3 weeks after giving birth, puppies younger than 3 weeks of age, as well as patients with infectious diseases, recovering and exhausted animals. Do not prescribe paste at the same time as piperazine derivatives and other cholinesterase inhibiting drugs.
Special instructions
When used according to the instructions, special instructions are not required.
In case of significant overdose, the animal may experience depression, refusal to feed, excessive salivation, and gastrointestinal upset. In these cases, apply general measures aimed at removing the drug from the body.
Dirofen paste 60 should not be used simultaneously with piperazine and cholinesterase inhibiting agents.
Violations of the recommended time for deworming of animals should be avoided, as this may lead to a decrease in efficiency. If the next deworming is skipped, the use of Dirofen paste 60 is resumed in the same dose, according to the same scheme.
Dirofen-paste 60 is not intended for use by productive animals.
Composition
In 1 ml as
active ingredients: pyrantel pamoate – 45 mg and praziquantel – 15 mg,
excipients: pumpkin oil – 5 mg, tween-80 – 5 mg, cyclamate saccharin and aspartame – 0.5 mg each, sodium benzoate – 1.5 mg, Na-carboxymethyl cellulose – 15 mg and distilled water – up to 1 ml.
Dosage and administration of
Dirofen paste is given to the animals inside once individually in the morning feeding with a small amount of feed or injected or injected into the oral cavity by squeezing the paste for adult dogs and cats from the syringe-dispenser – 1 ml of Dirofen paste 60 per 3 kg mass of the animal. A preliminary fasting diet and the use of laxatives when using the drug are not required.
For prophylactic purposes, deworming is carried out every 3 months, as well as before each vaccination. Treatment measures against nematodes and cestodes are performed according to indications. With a strong degree of invasion, the paste is set again after 10 days. For pregnant females, the drug is prescribed 3 weeks before the expected birth with caution, under the supervision of a veterinarian, nursing females – 2 to 3 weeks after the birth.
Side effects of
When using Dirofen paste 60 in accordance with this instruction, side effects and complications in animals are usually not observed. With increased individual sensitivity to the components of the drug and the appearance of side effects and complications, the use of the drug is stopped and desensitizing therapy is carried out.
