Description
Pharmacological action of
Dirofen suspension refers to combination anthelmintic drugs. It has a wide spectrum of anthelmintic action on sexually mature and larval stages of development of round and ribbon helminths, parasitic in dogs, cats, and ferrets (Tohosara sanis, Tohosara mystax, Toxascaris leonina, Taenia solium, Uncinaria stenocephala, Trichuris vulpis, Ancylostoma caninum, Echinococcus granulosus, Dumomicellumomitumomicomidumumomocomus multilocularis, Idumomocomus multilocularis, Idumomicellum rodents (Syphacia obvelata, Syphacia muris, Aspiculuris tetraptera, Rodentolepis straminea, Hymenolepis nana, Hymenolepis diminuta).
The mechanism of action of the praziquantel and pyrantel pamoate, which are part of the drug, is based on the inhibition of fumarate reductase, persistent depolarization of the helminth muscle cells, impaired energy metabolism, which causes paralysis and death of helminths and helps to eliminate them from the gastrointestinal tract.
When administered orally, praziquantel is rapidly absorbed in the gastrointestinal tract, reaching a maximum plasma concentration after 1-3 hours, and is distributed in the animal ² ¢s organs and tissues, excreted mainly in the urine (up to 80%) within 24 hours . Pyrantel pamoate is poorly absorbed, which ensures its prolonged effect on helminths in the intestine, is excreted from the body mainly in unchanged form with feces (93%).
Dirofen suspension by its degree of exposure to the body belongs to low-hazard substances (hazard class 4 according to GOST 12.1.007-76), at the recommended doses they do not have embryotoxic, teratogenic and sensitizing effects. Well tolerated by dogs and cats of different breeds and ages, ferrets and decorative rodents.
Indications
Dirofen suspension 60 is prescribed for adult dogs and cats for prophylactic and therapeutic purposes in case of nematodoses (toxocariasis, toxascaridosis, uncinariosis, trichocephalosis, ankylostomosis), cestodoses (tenidiosis, dipodicosis, diacodiosis dioxydosis) .
Contraindications
Contraindication to use is individual intolerance to the components of the drug (including a history).
Dirofen suspension should not be used in malnourished patients with infectious diseases and recovering animals, nor should females in the first half of pregnancy, puppies, kittens, rodents and ferrets under 3 weeks of age.
Pregnant females, if necessary, prescribe the drug 3 weeks before the expected birth with caution, under the supervision of a veterinarian, lactating females – 2-3 weeks after birth.
Special instructions
Dirofen suspension should not be used simultaneously with piperazine and cholinesterase inhibitors.
The drug is not intended for use by productive animals.
Composition
Drug Dirofen suspension 60 (for adult cats and dogs), contains 1 ml as active ingredients: pyrantel pamoate – 45 mg and praziquantel – 15 mg, as well as excipients: pumpkin oil, tween-80, aspasvit C 200, sodium benzoate, Na-carboxymethyl cellulose and purified water.
Side effects of
When using Dirofen suspension in accordance with this instruction, side effects and complications in animals, as a rule, are not observed. With increased individual sensitivity to the components of the drug and the appearance of allergic reactions, its use is stopped and antihistamines and symptomatic therapy are prescribed to the animal.
Storage conditions
Store the drug in the manufacturer s closed packaging, in a place protected from direct sunlight, separate from food and feed at a temperature of 0 ° C to 25 ° C.
Dirofen suspension should be stored out of the reach of children.
Expiration date
Expiration date subject to storage conditions – 2 years from the date of production, after opening the bottle – 90 days.
Active ingredient
Pyrantel, praziquantel
dosage form
oral suspension
