Description
Pharmacological action
Dironet ® 200 has a wide spectrum and nematodotsidnogo tsestodotsidnogo action, active against round and ribbon helminths parasitic in dogs and cats, including Toxocara canis, T. cati, Toxascaris leonina, Uncinaria stenocephala, Ancylostoma caninum, Trichuris vulpis, Echinococcus granulosus, E. multilocularis, Diphylloipylum latumidum latumidum latumidum latumidum Multiceps multiceps, Taenia spp., As well as the larval developmental phases (microfilariae) Dirofilaria immitis and Dirofilaria repens.
The mechanism of action of ivermectin consists in binding to glutamate-dependent chlorine channels, located mainly in the swallowing and somatic muscles. As a result, the membrane permeability for chlorine ions increases, the transmission of a neuromuscular impulse is blocked, paralysis and death of the parasite occur.
The mechanism of action of the pyramid pamoate is to block neuromuscular transmission, impaired permeability of cell membranes and inhibition of cholinesterase, which also leads to paralysis and death of the parasite.
The mechanism of action of praziquantel is based on impaired glucose transport and microtubular function in cestodes, inhibition of fumarate reductase activity and ATP synthesis, increased permeability of cell membranes and impaired muscle innervation.
Indications
Prevention of dirofilariasis, as well as treatment and prevention of nematodoses and cestodoses in cats.
Contraindications
Do not use the drug in females during pregnancy and lactation, as well as puppies and kittens younger than 3 weeks of age. Do not use the drug in animals weighing less than 0.5 kg.
Composition
Dironet ® 200 for dogs of small breeds and puppies, contains in one biconvex tablet of pyrantel pamoate 60 mg, praziquantel 20 mg and ivermectin 0, 024 mg.
Dosage and administration of
In case of cestodoses and nematodoses of the gastrointestinal tract Dironet ® 200, they are used individually and once daily for morning feeding in the following doses: pyrantel pamoate – 15 mg / kg, praziquantel – 5 mg / kg, – 0, 006 mg / kg, based on 1 tablet of Dironet ® 200 per 4 kg of the weight of cats and kittens.
For preventive purposes, deworming is carried out quarterly, as well as before each vaccination.
To reduce the number of microfilariae circulating in the blood of invaded D. immitis or D. repens animals, the drug is prescribed in a therapeutic dose once, once a month.
In order to prevent dirofilariasis in the disease-disadvantaged region, Dironet ® 200 is used in the spring-summer-autumn period: once before the summer of mosquitoes (March-April), then monthly from April to October, and last time in the season 1 month after the end of the summer of mosquitoes (October-November).
Side effects
When using the drug according to the instructions, side effects and complications are not observed.
Storage conditions
Dironet ® 200 tablets are stored in the manufacturer ² ¢s sealed packaging, protected from light and moisture, separately from food and feed, at a temperature of 0 ° C to 25 ° C, inaccessible to children and animals.
dosage form
tablets
