Description
Pharmacological action of
Onsior tablets refers to non-steroidal anti-inflammatory drugs.
Robenacoxib, which is part of the drug, – non-steroidal anti-inflammatory drug of the coxib group, is a selective specific COX-2 inhibitor and has an anti-inflammatory and analgesic effect. COX is presented in two forms: COX-1 – the constitutive form of the enzyme – performs protective functions, including in the gastrointestinal tract and kidneys COX-2 – the inducible form of the enzyme – is responsible for the production of mediators, including PGE, which cause pain, inflammation and fever . When administered orally, robenacoxib is rapidly absorbed in the intestine, entering the systemic circulation and most organs and tissues of more than 99% of robenacoxib binds to plasma proteins. Its maximum plasma concentration is observed after 0.5 hours, bioavailability is 49% in cats and 62% in dogs when using tablets with food and 84% without food. Robenacoxib is metabolized in the liver, excreted mainly with bile (about 70% in cats and about 65% in dogs) and partially with urine, the half-life of dogs from the body is about 1.2 hours, cats – 1.7 hours. Onsior ² Ñ tablets, according to the degree of exposure to the body, are classified as moderately hazardous substances (hazard class 3 according to GOST 12.1.007).
Indications
Onsior tablets are prescribed for dogs and cats as anti-inflammatory and painkillers for inflammatory and pain syndromes of various origins, including acute and chronic diseases of the musculoskeletal system (arthritis, arthrosis, synovitis, sprains), inflammatory soft tissue diseases, as well as as an analgesic and anti-inflammatory drug in the postoperative period.
Contraindications
It is forbidden to use Onsior tablets to animals in a state of dehydration, hypovolemia and hypotension, as well as animals weighing less than 2.5 kg. If it is absolutely necessary to prescribe a drug for such animals, treatment is carried out under the constant supervision of a veterinarian. Contraindication to use is an individual hypersensitivity of the animal to the components of the drug. The drug should not be used in animals with severe cardiac, renal and hepatic insufficiency.
Special instructions
Onsior tablets should not be used simultaneously with other non-steroidal anti-inflammatory drugs and within 24 hours after their withdrawal, diuretics, as well as ACE inhibitors and other drugs with a high degree of binding to blood serum proteins due to the likelihood of mutual amplification of toxic actions. The drug is not intended for use by productive animals.
Composition
Onsior tablets for cats contain robenacoxib – 6 mg / tablet as an active ingredient. As an auxiliary substance, Onsior tablets contain: yeast, microcrystalline cellulose, flavor identical to beef, powdered cellulose, povidone (K-30), crospovidone, colloidal anhydrous silicon dioxide and magnesium stearate.
Side effects
When using Onsior tablets in accordance with these instructions, side effects and complications in animals, as a rule, are not observed. In cats, gastrointestinal upsets (vomiting, mild feces or diarrhea) are possible, these symptoms go away spontaneously and do not require the use of drugs. With individual hypersensitivity of the animal to the drug and the appearance of allergic reactions, the use of the drug is stopped and the animal is prescribed antihistamines and symptomatic agents.
Storage conditions
Store Onsior tablets in the manufacturer’s sealed packaging in a place protected from direct sunlight, separate from food and feed, at a temperature of 0 ° C to 25 ° C. Keep out of the reach of children. Unused drug is disposed of in accordance with legal requirements.
Shelf life
4 years.
Active ingredient
Robenacoxib
Dosage The shape of the tablets
