Description
Description
Sustained-release tablets coated with a dark blue film coating, round, biconvex in cross section, two layers are visible – a white or almost white core and a film coating.
Pharmacological action
Selective inhibitor of cycloguanosine monophosphate (cGMP) -specific PDE5. PDE5, responsible for the breakdown of cGMP, is found not only in the cavernous body of the penis, but also in the vessels of the lungs. Restores impaired erectile function and provides a natural response to sexual arousal. Sildenafil does not have a direct relaxing effect on the cavernous body, but it actively enhances the relaxing effect of nitric oxide on this tissue. With sexual arousal, a local release of NO under the influence of sildenafil leads to inhibition of PDE5 and an increase in the level of cGMP in the cavernous body, as a result of which there is a relaxation of smooth muscles and increased blood flow in the cavernous body. Being an inhibitor of PDE5, Sildenafil increases the content of cGMP in the smooth muscle cells of the pulmonary vessels and causes their relaxation. In patients with pulmonary hypertension, taking sildenafil leads to vasodilation of the lungs and, to a lesser extent, other vessels. Sildenafil is selective for PDE5 in vitro. Its activity in relation to PDE5 is superior to activity against other known PDE isoenzymes: PDE6, which is involved in the transmission of the light signal in the retina of the eye – 10 times PDE1 – 80 times PDE2, PDE4, PDE7-PDE11 – more than 700 times. The activity of sildenafil in relation to PDE5 is more than 4000 times greater than its activity against PDE3, a cAMP-specific PDE involved in heart contraction. Sildenafil can cause a mild and transient impaired color discrimination (blue / green). The supposed mechanism of color vision impairment is considered to be the inhibition of PDE6, which is involved in the process of light transmission in the retina. In vitro studies have shown that the effect of sildenafil on PDE6 is 10 times less than its activity against PDE5.
Indications
The drug is used to treat potency disorders, expressed by the inability to achieve or retain an erection of the genital organ to ensure full sexual intercourse. The active substance of the drug (sildenefril) is effective only when exposed to sexual arousal.
Contraindications
Before taking this drug, you should consult a doctor, because there are some contraindications: srdlkrp is individual or other component
, which is part of the drug, suffered a heart attack, stroke
six months ago, rehabilitation period after abdominal surgery
chronic heart disease a and
vascular system is not intended for boys under 18 years
hepatic failure, liver cirrhosis
renal failure in chronic
degenerative changes of the retina is not intended for receiving women.
Recommendations for the use of
Treatment of erectile dysfunction: taken orally about 1 hour before the planned sexual activity. A single dose is 50 mg. Given the effectiveness and tolerability, the dose can be increased to 100 mg or reduced to 25 mg. The maximum single dose is 100 mg. The maximum frequency of use is 1 time / day. For elderly patients over the age of 65 and with concomitant impaired renal or hepatic function, the dose is 25 mg. Pulmonary hypertension: by mouth, 20 mg 3 times / day with an interval of about 6-8 hours, regardless of food intake. The maximum daily dose is 60 mg. Dose adjustment is not required for patients with impaired renal function, but with poor tolerance, the dose is reduced to 20 mg 2 times / day.
Special instructions
Before taking sildenafil for the treatment of erectile dysfunction, an examination of the cardiovascular system should be carried out. Caution should be used in patients with anatomical deformation of the penis (e.g., angulation, cavernous fibrosis or Peyronie’s disease) and people with diseases that predispose to the development of priapism (such as sickle cell anemia, multiple myeloma or leukemia). It should not be used in patients for whom sexual activity is undesirable. Use with caution in patients with a tendency to bleeding, with peptic ulcer of the stomach and duodenum in the acute phase, with hereditary retinitis pigmentosa. Sildenafil is not used in patients under the age of 18 years. Impact on the ability to drive vehicles and control mechanisms Sildenafil does not affect the ability to drive vehicles and control mechanisms.
Side effects of
Like any medicine, Vildegra has side effects:
nervous system: headache, possibly dizziness, drowsiness, sometimes fainting, stroke (rarely), seizures
cardiovascular system: tachycardia, (rarely) increase (decrease) ) blood pressure, myocardial infarction (rare)
organs of vision: visual impairment, color perception
hearing organs: tinnitus, sometimes vertigo
respiratory organs: symptoms of a runny nose (nasal congestion), nosebleeds (rarely)
musculoskeletal Single system: myalgia (muscle pain)
gastrointestinal tract: dyspepsia, rarely vomiting, sometimes nausea
in the genital area: rarely – hematospermia (blood admixture in semen), genital bleeding, extremely rare – priapism (prolonged and painful erection , not associated with sexual arousal), prolonged erection
allergic manifestations: very rarely – rashes on the skin
other: sudden fatigue, chest pain.
Dosage form
tablets
