Description
Pharmacological action of
Stop coccid belongs to the antiaccidia group of the triazintrione group.
Toltrazuril, which is part of the drug, has a wide spectrum of coccidiocidal action at the stages of intracellular development of parasites, is effective against all types of coccidia, including Eimeria spp., Isospora spp., Cistoisospora spp., parasitizing in piglets, calves, lambs, rabbits, puppies of dogs and fur animals.
Toltrazuril has a damaging effect on mitochondria and the processes of fission of the coccidia nucleus, disrupting the formation of macrogametocytes, blocking respiratory enzymes, and causing death of parasites.
After oral administration of the drug, toltrazuril is slowly absorbed and has a coccidiocidal effect on the mucous and submucous membranes of the gastrointestinal tract.
In the body, toltrazuril is metabolized by sulfoxidation and hydroxylation, with the formation of sulfoxide and sulfone.
It is excreted mainly in an unchanged form – up to 70%, as well as in the form of metabolites with feces and partially with urine.
Stop coccid according to the degree of exposure to the body refers to low-hazard substances (hazard class 4 according to GOST 12.1.007-76), in recommended doses, it does not cause side effects and complications in animals, does not prevent the formation of immunity to coccidiosis.
Indications
Stop coccid is given to calves, lambs, kids, piglets, rabbits, puppies and fur animals for the treatment and prevention of coccidiosis.
Contraindications
Contraindication to the use of Stop Coccid is an increased individual sensitivity of the animal to the components of the drug, serious impairment of liver and / or kidney function.
Do not use the drug in adult ruminants with advanced cicatricial digestion.
Composition
Stop coccid in 1 ml contains toltrazuril – 50 mg as an active ingredient, as well as excipients: sodium benzoate, potassium sorbate, croscarmellose sodium, aspartic acid C 200, lactose, tween-80, aerosil, propylene glycol, xanthan gum citric acid Dimethicone and purified water.
Dosage and administration
Stop coccid is administered individually to animals orally with a dosing syringe or mixed with a small amount of feed. In case of sediment, the container with suspension should be thoroughly shaken before use.
Doses and dosage regimens are presented in the table.
Table
Type of animal
Age
Dose of the drug per 1 kg of animal weight
Frequency and duration of the drug
AI, mg / kg
suspension, ml / kg
Calves, lambs and goats
from 14 days
from 15 days
once
pigs from 3 days
20
0.4 (not less than 0.5 and not more than 2 ml / animal)
once
dog puppies from 14 days
10
0.2
once a day, 3 consecutive days
Rabbits
from 28 days 7 0.14 One-time
Minks
from 28 days 20 0.4 One-time
Arctic foxes and foxes
from 28 days 10 0.2 One-shot
In coccidiosis dysfunctional farms to achieve the maximum preventive effect reduce the number of oocysts secreted into the environment, the drug should be prescribed to susceptible animals until the first clinical signs of the disease appear in the herd.
Overdose of
With an overdose of the drug, an animal may experience a decrease in appetite, a decrease in water intake, an upset gastrointestinal tract, and vomiting.
Storage conditions
Store the drug in the manufacturer ² ¢s sealed packaging, in a place protected from direct sunlight, separate from food and feed at temperatures from 0 ° C to 25 ° C.
Dosage form
suspension for oral administration
