umifenovir – Afludol tablets coated captive. about. 50 mg 20 pcs

$17.00

Description

Pharmacological action

Pharmacotherapeutic group: Antiviral.

ATX code: J05AX13

Pharmacological properties of

Pharmacodynamics

Antiviral. Specifically inhibits influenza A and B viruses, the coronavirus associated with severe acute respiratory syndrome (SARS). According to the mechanism of antiviral action, it belongs to fusion (fusion) inhibitors, interacts with the hemagglutinin of the virus and prevents the fusion of the lipid membrane of the virus and cell membranes. It has a moderate immunomodulatory effect. It has interferon-inducing activity, stimulates humoral and cellular immunity reactions, macrophage phagocytic function, increases the body’s resistance to viral infections. It reduces the incidence of complications associated with a viral infection, as well as exacerbations of chronic bacterial diseases.

Therapeutic efficacy in viral infections is manifested in a decrease in the severity of general intoxication and clinical phenomena, a reduction in the duration of the disease, and a decrease in the risk of complications.

Refers to low-toxic drugs (LD50> 4 g / kg). It does not have any negative effects on the human body when administered orally in recommended doses.

Pharmacokinetics

Absorption – fast. It is quickly distributed to organs and tissues. The time to reach maximum concentration when taken in a dose of 50 mg is 1.2 hours, in a dose of 100 mg – 1.5 hours. It is metabolized in the liver. The elimination half-life is 17-21 hours. About 40% is excreted unchanged, mainly with bile (38.9%) and in a small amount by the kidneys (0.12%). During the first day, 90% of the administered dose is excreted.

Contraindications

Hypersensitivity to umifenovir or any component of the drug, lactose deficiency, lactose intolerance, glucose-galactose malabsorption, children under 3 years of age.

Ingredients

Active ingredient: Umifenovir hydrochloride monohydrate in terms of Umifenovir hydrochloride – 0.0500 g.

Excipients monohydrate – 0.0861 g, povidone K-25 (polyvinylpyrrolidone medium molecular weight) – 0.0032 g, crospovidone – 0.0047 g, colloidal silicon dioxide (aerosil) – 0.0045 g, magnesium stearate – 0.0015 g.

Auxiliary sheath substances: Opadry II white [lactose monohydrate – 36%, hypromellose – 28%, dioxide Titan – 26%, macrogol 4000 (polyethylene glycol 4000) – 10%] – 0.0060 g

Dosage and Administration

Inside. Before eating.

Single dose (depending on age):

Age Single dose of the drug

From 3 to 6 years old 50 mg (1 tablet 50 mg)

From 6 to 12 years old 100 mg (2 tablets 50 mg or 1 tablet 100 mg )

Older than 12 years old and adults 200 mg (4 tablets of 50 mg or 2 tablets of 100 mg)

Indication of the drug

In children from 3 years of age and adults:

Non-specific prophylaxis during the flu epidemic and other acute respiratory viral infections In a single dose 2 once a week for 3 weeks.

Non-specific prophylaxis in direct contact with patients with influenza and other acute respiratory viral infections In a single dose 1 time per day for 10-14 days.

Treatment of influenza and other acute respiratory viral infections in a single dose 4 times a day (every 6 hours) for 5 days.

Complex therapy of chronic bronchitis, pneumonia and recurrent herpes infection In a single dose 4 times a day (every 6 hours) for 5-7 days, then a single dose 2 times a week for 4 weeks.

Prevention of postoperative infectious complications In a single dose 2 days before surgery, then 2 and 5 days after surgery.

Side effects

Rarely – allergic reaction.

Overdose

Not observed.

Storage conditions

At a temperature not exceeding 25C. Keep out of the reach of children.

Expiration

2 years.

Deystvuyuschee substances

Umyfenovyr

Terms and conditions otpuska IZ drugstore

Without prescription

dosage form

tablets

Indications

Prevention hryppa and prostud , Hrypp, Colds