Description
Pharmacological action
Imidacloprid and permethrin, which are part of the Advantix, exhibiting a synergistic effect, have a systemic, contact and repellent effect on insects and ixodid ticks. The drug is effective against the imaginal and preimaginal phases of the development of lice, fleas, lice beetles and ixodid ticks, protects animals from mosquitoes, midges and mosquitoes. The mechanism of action of synthetic pyrethroid permethrin is to block the transmission of nerve impulses, which causes impaired coordination of movements, paralysis and death of ectoparasites. Imidacloprid belongs to the group of chloronicotininyl insecticides, the mechanism of action of which is based on the interaction with acetylcholine arthropod receptors and impaired transmission of nerve impulses. Acting as an arthropod nerve activator, imidacloprid enhances the insect-acaricidal effect of permethrin. After applying Advantix, its active components, practically not absorbed into the systemic circulation, are quickly distributed on the surface of the body and are retained on the epidermis and coat, have a long contact insect-acaricidal and repellent effect. According to the degree of toxic effects on the body, advantix is ​​a moderately hazardous substance, at the recommended doses it does not have a resorptive-toxic, embryotoxic, teratogenic, mutagenic and sensitizing effect, when it gets into the eyes it causes slight irritation. The drug is toxic to cats, bees, as well as fish and other aquatic organisms.
Contraindications
Use of Advantix for cats is prohibited. It is not allowed to apply to patients with infectious diseases and recovering dogs, puppies under 7 weeks of age and / or weighing less than 1.5 kg, as well as animals of other species. Use with caution in pregnant and lactating females. The simultaneous use of Advantix with other insect-acaricidal drugs is not allowed.
Special instructions
Due to possible contamination of the preparation with fabrics, plastic and other materials, the treated animal should not be allowed to come into contact with the surrounding objects until the preparation has completely dried at the treatment site. During processing, the animal is not allowed to smoke, drink or eat. At the end of the procedure, wash your hands thoroughly with warm water and soap. Advantix is not recommended to be applied to wet or damaged skin, to wash the animal for 7 days after treatment with the drug. The animal should not be washed, ironed and kept out of reach of small children within 24 hours after treatment with the drug. In case of accidental contact with the skin or eyes, rinse it off immediately with a stream of water, if swallowed, consult a medical doctor.
Composition
Combined insect-acaricidal preparation containing 10% imidacloprid {1- (6-chloro-3-pyredylmethyl) -N-nitro-imidazolidin-2} and 50% permethrin {3-phenoxybenzyl-2, as active ingredients 2-dimethyl-3- (2,2-dichloro-vinyl) -cyclopropane carboxylate}, as well as auxiliary components.
Dosage and administration
The drug is applied by topical (drip) application of the drug to dry, intact skin. Before use, the protective membrane of the nozzle of the tube-pipette is pierced (putting on the cap on the back side), spreading the wool and pressing the tube-pipette, apply the drug to the skin in an inaccessible place for licking to the animal (between the shoulder blades). When treating large dogs, the contents of the tube-pipette are applied to the skin in three to four places on the back from the shoulder blades to the sacrum. The death of parasitic insects on an animal occurs within 12 hours, the death or detachment of ixodid ticks occurs within 48 hours after treatment. The repellent effect of the drug against lice, fleas, withers, dipterous blood-sucking insects, as well as ticks after a single treatment of the animal lasts 4-6 weeks. Repeated treatment of animals is carried out according to indications, but not more than 1 time per month. In the treatment of allergic dermatitis caused by insects, the drug should be used in combination with drugs of pathogenetic and symptomatic therapy.
The active ingredient imidacloprid, permethrin
