Description
Latin name
Intralipid
Packaging
10 vials of 100 ml.
Indications
Parenteral nutrition (as a source of energy and essential fatty acids). Intralipid is especially necessary in conditions associated with hypercatabolism: sepsis, polytrauma, severe burns, etc.
Essential fatty acid deficiency. (For patients with a deficiency of essential fatty acids, unable to independently replenish the normal balance of essential fatty acids through oral consumption).
Contraindications
The acute stage of shock, hypersensitivity to the components of the drug, severe lipid metabolism disorders, for example, with pathological
hyperlipidemia.
Caution: diseases that cause lipid metabolism disorders: severe renal and / or liver failure, decompensated diabetes mellitus, pancreatitis, hypothyroidism (with concomitant hypertriglyceridemia), soy protein allergy (only after allergic tests).
Use during pregnancy and lactation
Use during pregnancy and lactation is effective and safe.
Ingredients
Active substances: purified soybean oil 200 g egg yolk phospholipids 12 g glycerol (anhydrous) 22 g of sodium hydroxide to pH 8 (for pH correction) qs, water for injection.
Dosage and Administration
Dose and route of administration should be determined by the ability to eliminate intralipid.
Adults. The maximum daily dose of 3 g of triglycerides per 1 kg of body weight per day (15 ml of Intralipid 20%). The infusion time of 500 ml of Intralipid 20% – at least 5 hours. Intralipid can cover up to 70% of energy needs.
Newborns and young children. The daily dose is from 0.5 to 4.0 g of triglycerides per 1 kg of body weight per day, which corresponds to 2.5-20 ml of Intralipid 20%. The infusion rate is not more than 0.15 g / kg / h.
Drug Interactions
Intralipia may be coadministered with Vitalipid Adult and Vitalipid Pediatric, Soluvit.
Mixing solutions should be carried out under aseptic conditions.
Heparin causes a transient increase in plasma lipolysis, which leads to a temporary decrease in triglyceride clearance due to inhibition of lipoprotein lipase.
Insulin can also affect lipase activity, but there is no evidence of an adverse effect of this factor on the therapeutic value of the drug.
overdose
Symptoms: Intralipid elimination disorders can lead to the development of excessive fat syndrome, which in turn can lead to renal dysfunction or infection. The syndrome of excessive fat load is characterized by hyperlipidemia, fever, fatty infiltration, impaired function of various organs and coma.
Treatment: Termination of Intralipid infusion leads to the disappearance of all symptoms.
Storage conditions
Store in a dark place at a temperature not exceeding 25 ° C. Do not freeze.
shelf life
2 years
Pharmacy terms
Prescription
dosage form
emulsion for infusion
Possible product names
Intralipid 20% 100 ml No. 10 fl
INTRALIPID 20% 100ML N10 FLAC EMULSION / S HOLD /
Intralipid vials 20%, 100 ml, 10 pcs.
INTRALIPID EMULSION D / INF. 20% FL. 100ML 10
Fresenius Kabi, Germany
