Description
Pharmacological action
Antispasmodic myotropic action, It has a direct effect on the smooth muscles of the gastrointestinal tract (mainly the large intestine). Eliminates spasm without affecting normal intestinal motility. Inhibits phosphodiesterase. It stabilizes the level of cyclic adenosine monodiphosphoric acid. It does not have an anticholinergic effect.
Pharmacokinetics
When administered orally, it undergoes presystem hydrolysis and is not detected in plasma. It is metabolized in the liver to veratric acid and mebeverine alcohol. It is excreted mainly by the kidneys in the form of metabolites, in small quantities by bile. Mebeverin capsules have the property of prolonged release. Even after repeated administration, no significant cumulation is observed.
Indications
In adults:
spasm of the gastrointestinal tract (including that caused by an organic disease)
intestinal colic
biliary colic
irritable bowel syndrome.
In children over 12 years of age:
functional disorders of the gastrointestinal tract, accompanied by abdominal pain.
Contraindications
Hypersensitivity
porphyria
pregnancy
children under 12 years of age (due to insufficient data on efficacy and safety).
Precautions: use during lactation.
Composition
1 caps.
mebeverine hydrochloride 200 mg
Excipients: silicon dioxide colloidal (aerosil) – 5 mg, hypromellose (hydroxypropyl methylcellulose) – 38 mg, povidone K90 – 5 mg, magnesium stearate – 2 mg.
Composition of hard gelatin capsule: case: titanium dioxide – 1.378 mg, gelatin – 44.522 mg, quinoline yellow dye – 0.308 mg, sunset yellow dye – 0.003 mg cap: titanium dioxide – 0.893 mg, gelatin – 28.686 mg, quinoline yellow dye – 0.199 mg, dye sunny sunset yellow – 0. 002 mg.
Dosage and administration
Inside adults and children over 12 years old, 1 capsule (200 mg) 2 times / day 20 minutes before meals (morning and evening). Swallow whole with water.
Side effects
Dizziness, headache, diarrhea, constipation.
Allergic reactions: urticaria, Quincke’s edema, facial edema and exanthema.
Overdose of
Symptoms: CNS arousal. The specific antidote is unknown. Gastric lavage and symptomatic therapy are recommended.
Storage conditions
The drug should be stored in a dry, dark place and out of the reach of children at a temperature not exceeding 25 ° C.
Do not use after expiration date.
Shelf life
2 years.
active substance
Mebeverin
Pharmacy terms
prescription
Appointment
Adults prescribed by a doctor
Indications
of meteorism, from spazmov ZHKT, dyskinesia zhelchev vodyashtih Putten
