Description
Pharmacological action
Bravecto refers to systemic insecticaricidal drugs. Fluralaner included in the preparation – (4- [5- (3,5-dichlorophenyl) -5- (trifluoromethyl) -4H-isoxazol-3-yl] -2-methyl-N- [2-oxo-2- (2 , 2,2-trifluoroethylamino) ethyl] benzamide) – an insectoacaricide of the isoxazoline group, It is active against fleas (Ctenocephalides felis and Ctenocephalides canis) and ticks (adults and larvae of Ixodes ricinus, Ixodes hexagonus, Ixodes scapularis, Ixodes holocyclus, Dermacentor reticulus parasius, Dermacentorphus parasibilis and Dermacentor variusus parabilis and The mechanism of action of fluralaner is to block GABA-dependent and glutamate-dependent arthropod receptors, hyper-excitation of neurons, impaired transmission of nerve impulses, which leads to paralysis and death of ectoparasites. After oral administration of the drug, fluralaner is easily absorbed in the gastrointestinal tract and reaches the systemic circulation, the maximum concentration in blood plasma is reached within 1 day, bioavailability is 20-27%, feed intake accelerates absorption. It is displayed fluralan slowly mainly in unchanged form with feces (~ 90% of the dose) and partially with urine, the elimination half-life is 12 days. The drug begins to act 4 hours after application and causes the death of fleas 8 hours after attachment to the body of the host, ticks – 12 hours later, preventing re-infection of dogs with ectoparasites. The death of fleas occurs before the laying of eggs, which prevents contamination of the premises with eggs and larvae.
According to the degree of exposure to the body, Bravecto belongs to the “low hazard” substances (hazard class 4 according to GOST 12.1.007-76), at the recommended doses it does not have an embryotoxic, teratogenic, mutagenic effect.
Indications
Bravecto is prescribed for dogs for the treatment and prevention of aphanipterosis, in the treatment of flea-caused allergic dermatitis, acaroses caused by ixodid ticks, for the treatment of demodicosis, sarcoptosis and otodectosis, as well as to reduce the risk of babesiosis.
Contraindications
Contraindication to use is individual intolerance to the components of the drug. The drug should not be used for puppies younger than 8 weeks of age and / or dogs weighing less than 2 kg. Bravecto is not intended for use by productive animals.
Recommendations for use
Bravecto is administered to dogs individually orally during or shortly before / after feeding at a therapeutic dose of 25-56 mg of fluralaner per 1 kg of animal weight. Bravecto has an attractive aroma and taste and, as a rule, is readily eaten by dogs otherwise, the drug is forcibly injected directly into the mouth or fed with food. Breaking tablets is not allowed. You should make sure that the dog has completely swallowed the required dose of the drug. Doses of the drug depending on the weight of the animal and the type of tablet used are presented in the table:
Weight
of the dog (kg)
Dose of active substance (mg / tablet) and the number of tablets
Bravecto
112.5
Bravecto
250
Bravecto
Bravecto
1000
Bravecto
1400
2-4.5
1
> 4.5-10
1
> 10-20
1
> 20-40
1
> 40-56
1
56
A combination of two tablets is selected based on 25-56 mg of fluralaner per 1 kg of animal weight
When using the drug for dogs weighing more than 56 kg, a combination of tablets is used based on 25-56 mg of fluralaner per 1 kg of animal weight. It is allowed to use the drug during lactation and lactation. Repeated treatments, if necessary, are carried out after 12 weeks.
Violations of the regimen of the drug should be avoided, as this may lead to a decrease in its effectiveness. If the next treatment is skipped, the use of the drug is resumed in the same dose according to the same scheme. Symptoms of an overdose have not been identified.
Special instructions
There are no specific effects on the first use of the drug and its withdrawal. With the simultaneous use of Bravecto with anthelmintics, antibiotics, non-steroidal anti-inflammatory drugs and glucocorticosteroids, undesirable reactions and a decrease in the effectiveness of the drug were not detected.
Composition
As an active ingredient, fluralaner, 500 mg in 1 tablet.
In appearance, the drug is a tablet from light brown to dark brown in round shape with a smooth or slightly rough surface, interspersing is possible.
Side effects
Side effects and complications when using the drug in accordance with the instructions, as a rule, are not observed. In rare cases, vomiting, diarrhea, loss of appetite and salivation are possible. If the dog has vomited within the first two hours after taking Bravecto, it is recommended to make sure that the vomiting has stopped and give the drug again in the same dose.
dosage form
tablets
