Description
Pharmacological action
Antibacterial drug group fluoroquinolones. The drug has a wide spectrum of bactericidal action, based on the suppression of the bacterial enzymes DNA gyrase and topoisomerase IV, which are involved in the replication of DNA of microorganisms.
Marbofloxacin, the active substance of Marfloxin, is active against gram-positive and gram-negative microorganisms, including Escherichia coli, Salmonella typhimurium, Citrobacter freundii, Enterobacter cloacae, Serratia marcescens, Morganella morganii, Proteus sppella. , Pasteurella spp., Haemophilus spp., Moraxella spp., Pseudomonas spp., Brucella canis, Staphylococci, Streptococci, as well as Mycoplasma spp.
After i / m and s / c administration of the drug at a dose of 2 mg / kg, marbofloxacin is well absorbed from the injection site and penetrates into most organs and tissues of the body. The bioavailability of marbofloxacin is more than 80%. The maximum concentration of marbofloxacin, about 0.5 Ојg / ml in piglets and 1 Ојg / ml in calves, in plasma is reached after 0.5-1.5 hours. Marbofloxacin weakly binds to blood plasma proteins, in pigs – by 10%, in cattle – thirty%. The concentration of marbofloxacin in organs is higher than the concentration in blood plasma. The half-life in calves is 5–9 hours, in cattle with cicatricial digestion, 4–7 hours, in pigs, 8–10 hours. Marbofloxacin is excreted from the body of animals mainly in unchanged form with urine and feces.
Marfloxin 2% solution for injection by the degree of exposure to the body refers to low-hazard substances.
Indications
Treatment in young cattle and pigs for infectious diseases caused by strains of microorganisms sensitive to marbofloxacin, including:
– respiratory infections.
Contraindications
– individual increased sensitivity of the animal to the components of the drug
– resistance of the pathogen to other fluoroquinolones.
It is not recommended to use the drug in animals with central nervous system lesions, as well as large breed puppies up to 18 months of age, and in other dog breeds – up to 12 months of age.
Recommendations for use
The drug is used in animals 1 time / day, in calves s / c, i / m or i / v, in pigs – i / m, in a daily dose of 2 mg / kg animal weight per active substance (corresponds to 1 ml of the drug per 10 kg).
The duration of treatment for young cattle and pigs is 3 to 5 days.
For the treatment of wound infections and abscesses in dogs, the drug is used sc once in a dose of 2 mg / kg (1 ml of the drug per 10 kg of animal weight), then treatment is continued using the drug Marfloxin® tablets.
In the treatment of infections of the urinary system in dogs, the drug is used at a dose of 4 mg / kg (2 ml of the drug per 10 kg of animal weight) s / c 1 time / day. The drug is administered 3 times with an interval of 4 days.
For the treatment of wound infections and abscesses in cats, the drug is used s / c 1 time / day at a dose of 2 mg / kg (0.5 ml of the drug per 5 kg of animal weight). Duration of administration is from 3 to 5 days.
For the prevention of wound infections during surgery in dogs and cats, the drug is administered at a dose of 2 mg / kg iv once immediately after surgery.
Features of the drug during its first use and withdrawal have not been established.
Avoid skipping the next dose, as this may lead to a decrease in therapeutic efficacy. If one dose is missed, the use of the drug is resumed in the same dose and in the same way.
Specific guidance
Studies in laboratory animals (rats and rabbits) have not revealed teratogenic and embryotoxic effects, as well as the negative effects of marbofloxacin on reproductive function in female animals. The drug can be used by pregnant and lactating sows. The possibility of using the drug MarfloxinВ® 2% solution for injection during pregnancy and lactation in dogs and cats is determined by the veterinarian based on an assessment of the ratio of the expected benefit to the possible risk of using the drug.
In case of allergic reactions, the use of the drug is stopped and antihistamines are prescribed to the animal, if necessary, symptomatic treatment is carried out.
It is not recommended to use MarfloxinВ® 2% solution for injection simultaneously with chloramphenicol, antibiotics of the macrolide group and the tetracycline group.
Slaughter of cattle for meat is allowed no earlier than 4 days, pigs – 3 days after the last use of the drug. Meat of animals forced to be killed before the expiration of the specified period can be used as feed for fur animals.
Composition of
1 ml contains: marbofloxacin 20 mg
excipients: metacresol – 2 mg, disodium edetate – 0.1 mg, monothioglycerol – 0.5 mg, gluconolactone – 16 mg, mannitol – 30 mg, water d / u – up to 1 ml .
Side effects
When using the drug at the recommended dose, no side effects were found in pigs and cattle. An inflammatory reaction may occur at the injection site.
In case of an overdose in animals, disturbances in the nervous system may be observed in cats and dogs, bradycardia may be observed. The treatment is symptomatic.
dosage form
injection
