Description
Pharmacological action
Fluralaner, which is part of the drug, is an acaricide and insecticide. It is effective against ticks (Ixodes spp., Dermacentor spp., Haemaphysalis elliptica and Rhipicephalus sanguineus), as well as Sarcoptes spp., Otodectes spp. and fleas (Ctenocephalides spp.).
Fluralaner is a potent inhibitor of certain parts of the arthropod nervous system, acting antagonistically on potential-independent carrier channels for chlorine ions (GABA receptor and glutamate receptor).
After topical administration, fluralaner is rapidly absorbed into the coat, skin and adjacent tissues, from where it slowly enters the vascular system. The plateau level is reached in plasma 7-63 days after application, after which the concentration slowly decreases. Fluralaner is well distributed in tissues and reaches high concentrations in adipose tissue, liver, muscles and kidneys. Long-term preservation and slow elimination from plasma and the absence of intensive metabolism provide effective concentrations of fluralaner during the time interval between applications of the drug. Fluralaner is excreted unchanged with excrement and, to a very insignificant degree, with urine.
Indications
Bravecto Spot It is used by cats to treat and prevent tick and flea infections, and also to treat otodectosis caused by Otodectes spp. It can be used as part of a comprehensive treatment for allergic dermatitis caused by fleas.
The prophylactic effect of infection with fleas and ticks of cats lasts for 12 weeks.
The effect after application of the drug develops within 12 hours (from fleas) and 48 hours (from ticks).
Contraindications
Contraindication to use is the individual hypersensitivity of the animal to the active substance or components of the drug.
Cautions for use in animals.
Avoid contact with the eyes of animals.
Do not apply directly to damaged skin.
Do not allow contact with treated areas (place of use) until dry.
Dogs and cats should not be allowed to swim in water, submerge in or wash them for 3 days after using the drug.
Due to lack of information, this drug should not be used: kittens less than 11 weeks of age and / or cats with body weight less than 1.2 kg.
Recommendations for use
Immediately before use, open one sachet bag and take out a pipette. To open, the pipette should be held at the base or at the top below the cap in an upright position (tip up). The screw cap is turned in the direction or counterclockwise one full revolution. The cap remains on the pipette – it cannot be completely removed. The pipette is open and ready for use when a click is felt from a broken seal.
For cats weighing more than 12.5 kg, use a combination of two pipettes, which is most suitable for body weight.
During the use of the drug, the cat should stand or lie so that its back is in a horizontal position. The pipette tip is placed above the cat’s head. Gently squeeze the pipette, applying the entire contents of the pipette directly to the cat’s skin. For cats weighing up to 6.25 kg, the drug should be applied in one place, in the area of the base of the skull for cats weighing more than 6.25 kg – in two places.
For optimal control of flea and tick infections, this drug should be used at 12-week intervals.
Special instructions
Dogs can use the drug during pregnancy and lactation. There are no data on the use of the drug in cats during pregnancy and lactation.
Composition
1.0 ml of the preparation contains 280 mg of fluralaner and excipients up to 1 ml.
In appearance, the drug is a clear solution from colorless to yellow.
Side effects
No side effects were observed after use in kittens aged 11-13 weeks (body weight 1.2 – 1.5 kg) overdose up to 5 times the maximum recommended dose 3 times with shorter intervals than recommended (at 8 week intervals). In cats, in some cases, skin reactions, in particular, redness or itching, may occur at the site of use. Shortly after use, lethargy / cramps / anorexia or nausea / increased salivation are possible.
dosage form
solution for externally Application of dosage form
