Description
Pharmacological action
The combined preparation has a local anticoagulant, anti-inflammatory, venotonic and antiplatelet effect, reduces the permeability of veins, improves microcirculation.
Detragel ® contains three active ingredients: heparin sodium, essential phospholipids and escin, which have pharmacodynamic and pharmacokinetic synergies.
Heparin sodium is a direct-acting anticoagulant. Due to the inactivation of biogenic amines and the blocking of lysosomal enzymes in the tissue, it exhibits anti-inflammatory effect, accelerates the dissolution of microthrombi in the area of ² ¹ ² ¹subcutaneous capillaries, prevents thrombosis, activates the fibrinolytic system, improves microcirculation, promotes the regeneration of connective tissue due to inhibition of the activity of hyaluronidase.
Essential phospholipids reduce blood viscosity due to the effect on the metabolism of fats, reduce platelet aggregation.
Escin is a venotonic agent of plant origin. It prevents the activation of lysosomal enzymes that break down proteoglycan, increases the tone of the venous wall, eliminates venous congestion, reduces the permeability and fragility of capillaries. Reduces exudation, reduces fluid effusion in the tissue and accelerates the resorption of existing edema. It inhibits inflammation, improves microcirculation, and promotes tissue repair.
Indications
therapy for the symptoms of chronic venous diseases
varicose veins with symptoms of pain, swelling, feeling of heaviness and fatigue in the legs, night cramps of the calf muscles and signs of telangiectasia (spider veins and reticulum) and varicose veins srd thrombophlebitis
hematoma with injuries, including sports sprains and bruises
postoperative hematomas without compromising the integrity of the skin.
Contraindications
hypersensitivity to the components of the drug
hemorrhagic diathesis (including thrombocytopenic purpura)
hemophilia
violation of the integrity of the skin at the site of application of the drug (open wounds, ulcerative necrotic lesions), burns, eczema, skin infections
is contraindicated for use on mucous membranes of
age up to 18 years (there is no experience with the drug in children under 18 years)
Directions for use
For external use.
Gel is applied in a thin layer to the problem area of the skin and evenly distributed with light massaging movements, 2-3 times / day daily until the symptoms disappear.
If necessary, the gel can be applied under elastic stockings or bandages.
For thrombophlebitis, rubbing the gel should be avoided.
Mucosal gel application is contraindicated.
Duration of treatment – no more than 15 days. The possibility of a longer course of treatment is determined by the doctor.
If the condition worsens or improvement does not occur after 15 days, the patient should consult a doctor.
Do not exceed the recommended dose and duration of the drug.
Special instructions
There have been no reports so far undesirable effects on the mother and fetus when using the drug in pregnant women.
Use during pregnancy and during breastfeeding is possible only in cases where the expected benefit Therapy for the mother outweighs the potential risk to the fetus, so consult a doctor before using the drug
Topical drugs, especially after prolonged use, have a sensitizing effect. drug treatment should be discontinued and, if necessary, appropriate treatment is prescribed.
With prolonged use of the drug on large areas of the skin and the simultaneous use of indirect anticoagulants (warfarin, acenocoumarol and others), prothrombin time and blood coagulation time should be monitored.
Detragel ® is not recommended for deep vein thrombosis.
If the patient’s condition worsens or improvement does not occur after 15 days, the patient should consult a doctor.
Composition of
Active ingredients in 1 g of the preparation:
sodium heparin 100 IU
essential phospholipids 10 mg
escin 10 mg
Storage conditions
The drug should be stored out of the reach of children at temperatures not exceeding 25 ° C.
Terms of
pharmacies vacation without prescription
Dosage form
gel for external use
For adults, Nursing mothers, Pregnant as prescribed by the doctor
Indications
Hematom , Ushyb , edema after injuries and operations, varicose veins, V vyhy and Stretch, thrombophlebitis
