Description
Release form
Chewable tablets (lemon).
Packing
60 pcs.
Pharmacological action
Calcium-D3 Nycomed forte regulates the exchange of calcium and phosphorus in the body (bones, teeth, nails, hair, muscles). Reduces resorption (resorption) and increases bone density, making up for the lack of calcium and vitamin D3 in the body, necessary for mineralization of the teeth.
Calcium is involved in the regulation of nerve conduction, muscle contractions and is a component of the blood coagulation system.
Vitamin D3 increases intestinal absorption of calcium.
The use of calcium and vitamin D3 prevents the increase in the production of parathyroid hormone (PTH), which is a stimulator of increased bone resorption (leaching of calcium from bones).
Pharmacokinetics
Calcium
Absorption. Typically, the amount of calcium absorbed in the gastrointestinal tract is approximately 30% of the dose taken.
Distribution and metabolism. 99% of the calcium in the body is concentrated in the rigid structure of bones and teeth. The remaining 1% is in intracellular and extracellular fluids. About 50% of the total calcium in the blood is in physiologically active ionized form, of which about 10% are in complex with citrate, phosphate or other anions, the remaining 40% are associated with proteins, primarily with albumin.
Withdrawal. Calcium is excreted by the intestines, kidneys and sweat glands. Renal excretion depends on glomerular filtration and tubular calcium reabsorption.
Vitamin D3
Suction. Vitamin D3 is easily absorbed in the small intestine (about 80% of the dose taken).
Distribution and metabolism. Colecalciferol and its metabolites circulate in the blood, associated with specific globulin. Colecalciferol is converted in the liver by hydroxylation to 25-hydroxycolcalciferol. Then it is converted in the kidneys into the active form of 1,25-hydroxycolcalcalciferol. 1,25-hydroxycolcalcaliferol is a metabolite responsible for increasing calcium absorption. Non-metabolized vitamin D3 is deposited in adipose and muscle tissue.
Withdrawal. Vitamin D3 is excreted by the intestines and kidneys.
Indications
Prevention and treatment of calcium and / or vitamin D3 deficiency
Prevention and treatment of osteoporosis (menopausal, senile, steroid, idiopathic).
Contraindications
hypersensitivity to one of the components of the drug Calcium-D3 Nycomed Forte
hypercalcemia, hypercalciuria
nephrolithiasis
hypervitaminosis D
severe renal failure
active tuberculosis
sarcoidosis
children under 3 years of age.
Caution: Pregnancy is a lactation period.
Use during pregnancy and lactation
The daily dose should not exceed 1500 mg of calcium and 600 IU of vitamin D3.
Hypercalcemia, which develops against the background of an overdose during pregnancy, can cause defects in the child s mental and physical development.
Vitamin D and its metabolites can pass into breast milk, so you must consider the intake of calcium and vitamin D from other sources in the mother and baby.
Dosage and administration
Inside, chewed or absorbed, mainly with meals.
For the prevention of osteoporosis
– 1 tablet 2 times a day or 2 tablets once a day
In the treatment of osteoporosis
– 1 tablet 2-3 times a day.
To make up for calcium and vitamin D deficiency: adults and children over 12 years old – 2 tablets per day, children 3-12 years old – 1 tablet per day or as directed by a doctor.
Special patient groups
Patients with impaired liver function. Dose adjustment is not required.
Patients with impaired renal function. The drug Calcium-D3 Nycomed should not be used in case of severe renal failure.
Elderly patients. The dose is the same as for adults. A possible decrease in creatinine clearance should be considered.
Duration of treatment. When used for prevention and in the treatment of osteoporosis, the duration of treatment is determined individually by the doctor.
When used to supplement calcium and vitamin D3 deficiency, the average duration of treatment is at least 4-6 weeks. The number of repeated courses throughout the year is determined individually.
Side effects
Allergic reactions
Gastrointestinal dysfunction (constipation or diarrhea, flatulence, nausea, abdominal pain)
Hypercalcemia and hypercalciuria.
Storage conditions
In a dark place at a temperature of no higher than 25 ° C, in a tightly closed package.
Expiration
3 years.
Deystvuyuschee substances
calcium carbonate, Kolekaltsyferol
dosage form
lozenges
Indications
In menopause, From bone fractures, During active growth, From osteoporosis, Insufficient nutrition
Takeda Pharmaceuticals Ltd., Russia
