Description
Latin name
Chondroxide
Release form
Tablets 250 mg. 10 tablets per blister pack. 3, 5, 6, 9 or 10 blister packs along with instructions for medical use of the drug are placed in a cardboard box.
packaging 60 pcs
Pharmacological action
Has chondrostimulating, regenerating, anti-inflammatory effect. Chondroxide ® is involved in the construction of the main substance of cartilage and bone tissue, affects metabolic processes in hyaline and fibrous cartilage, and inhibits enzymes that cause damage to cartilage. The drug inhibits the destruction of cartilage and stimulates regenerative processes in the articular cartilage.
Chondroxide ® stimulates the biosynthesis of proteoglycans, promotes the regeneration of the articular bag and cartilage surfaces of the joints, has an anti-inflammatory effect. It slows down bone resorption and reduces calcium loss, accelerates bone tissue repair processes.
Chondroxide ® slows the progression of osteoarthrosis and osteochondrosis. When using the drug Chondroxide ®, soreness decreases and the mobility of the affected joints improves, while the therapeutic effect persists for a long time after the end of the course of therapy.
Being structurally similar to heparin, it can potentially inhibit the formation of fibrin clots in the synovial and subchondral microvasculature.
Pharmacokinetics
Absorption
With a single oral administration of a medium therapeutic dose, the maximum plasma concentration is reached after 3-4 hours, in synovial fluid – after 4-5 hours. The bioavailability of the drug is 13%.
Distribution
It accumulates mainly in the cartilage (maximum concentration in the articular cartilage is reached after 48 hours), the synovial membrane is not an obstacle to its penetration into the joint cavity.
Excretion
Excreted by the kidneys within 24 hours.
Indications
Degenerative degenerative diseases of the joints and spine: treatment and prevention of osteoarthritis, spinal osteochondrosis.
Contraindications
Hypersensitivity to the drug, children’s age (efficacy and safety in children have not been established), pregnancy, period of breastfeeding.
Precautions
Bleeding, bleeding tendency.
Special instructions
When combined with indirect anticoagulants, antiplatelet agents, fibrinolytics, more frequent monitoring of blood coagulation is required.
Influence on the ability to drive vehicles and work with mechanisms
Does not affect the ability to drive a car and other mechanisms.
Composition
1 tablet contains:
Active ingredient: chondroitin sulfate – 250.0 mg (in terms of 100% dry matter)
Excipients – calcium stearate monohydrate (calcium stearate 1-water), crospovidone (10-XL, polyplasdone collidone CL-M), povidone K-30 (collidon 30), microcrystalline cellulose, magnesium hydroxycarbonate pentahydrate (basic magnesium carbonate aqueous).
Dosage and administration
Inside, 0.5 g (2 tablets) 2 times a day.
Tablets are taken with a little water.
The recommended initial course of treatment is 6 months. The therapeutic effect of the drug persists for 3-5 months after its withdrawal, depending on the location and stage of the disease. If necessary, it is possible to conduct repeated courses of treatment, the duration of which is determined individually.
Side effects
Frequency assessment: rarely – from> = 0.01% to <0.1%. Disorders of the gastrointestinal tract: rarely – nausea, vomiting, diarrhea. Disorders of the immune system: rarely – allergic reactions. Drug Interactions Possible increased effects of indirect anticoagulants, antiplatelet agents, fibrinolytics. overdose Symptoms: rarely – nausea, vomiting, diarrhea, with prolonged intake at excessively high doses (more than 3 g / day) hemorrhagic rashes are possible. Treatment: carrying out symptomatic therapy. Storage Conditions In a dry, dark place at a temperature not exceeding 25 ° C. Keep out of the reach of children. Shelf life 2 years. Deystvuyushtee substance chondroitin sulyfat Conditions of release from drugstores Prescription Dosage PMA Possible product names HONDROXID 0.250 N60 TABL Chondroxid 250m. X60 Chondroxide 250mg No. 60 HONDROXID 250MG. No. 60 TAB. / NIZHFARM / Chondroxide Tab 250mg N60 Nizhpharm, Russia
