Description
Latin name
Odeston
Packaging
20 pcs.
Pharmacological action
Clinical and pharmacological group: Drug with choleretic and antispasmodic
Pharmacotherapeutic group: Cholagogue
Pharmacological action
Cholagogue. Increases the formation and secretion of bile. It has a selective antispasmodic effect on the bile ducts and sphincter of Oddi. The drug does not reduce gastrointestinal motility and blood pressure.
Reduces stagnation of bile, prevents the crystallization of cholesterol and, thereby, the development of cholelithiasis.
Pharmacokinetics
Absorption and distribution of
After oral administration, it is rapidly absorbed from the digestive tract. Cmax in the blood after oral administration is achieved after 2-3 hours. It weakly binds to plasma proteins.
Excretion of
T1 / 2 is about 1 hour. Excreted in the urine: about 93% as glucuronate, 1.4% as sulfonate, 0.3% unchanged.
Indications
biliary dyskinesia and sphincter of Oddi hyperkinetic type
noncalculous chronic cholecystitis, cholangitis, cholelithiasis
condition after surgical interventions on bileMr. bladder and biliary tract
decreased appetite, nausea, constipation, vomiting (against the background of bile hyposecretion).
Contraindications
hypersensitivity
obstruction of the biliary tract
renal / hepatic insufficiency
ulcerative colitis, Crohn’s disease
peptic ulcer and duodenal ulcer
hemophilia.
Use during pregnancy and lactation
There is no data on the safety of the use of gimecromon during pregnancy and lactation.
Prescribing Odeston during pregnancy and lactation (breastfeeding) is permissible only in cases where the intended benefits to the mother outweigh the potential risk to the fetus or child.
Composition
Tablets from white to white with a yellowish tinge, round, flat-cylindrical, beveled and engraved on one side with the letters Ch.
1 tab.:
Gimekromon 200 mg
Excipients: potato starch – 45 mg, gelatin – 3 mg, sodium lauryl sulfate – 1 mg, magnesium stearate – 1 mg.
Dosage and administration
The drug is administered orally 30 minutes before a meal.
Adults are prescribed 200-400 mg 3 times / day. The daily dose is 1200 mg. The course of treatment is 2 weeks.
If you miss a dose, you must take the drug as soon as possible. If the time for the next dose is approaching, you should not take the missed dose. Do not take a double dose of the drug in order to compensate for the missed.
Side effects of the
From the digestive system: diarrhea, flatulence, abdominal pain, ulceration of the gastrointestinal mucosa.
Other: allergic reactions, headache.
Drug Interaction
Concomitant use of morphine, which causes a spasm of the Oddi sphincter, attenuates the effect of Odeton.
With simultaneous use of Odeton with metoclopramide, there is a mutual weakening of action.
Odeston enhances the effects of indirect anticoagulants.
Overdose
There have been no reports of an overdose of Odeton at this time.
Storage conditions
At a temperature not exceeding 25 ° C.
Shelf suitability
3 Year
Deystvuyuschee substances
Hymekromon
dosage form
dosage form
tablets
