Description
Latin name
Risedronic acid
Release form
Coated tablets.
Packing
In a blister pack of 4 tablets. In the package 1 blister.
Pharmacological action of
Risendros tablets is an inhibitor of bone resorption.
Risedronic acid binds to hydroxyapatite at the cellular level and inhibits the function of osteoclasts, reduces bone resorption.
Time to achieve maximum therapeutic effect – 3 – 6 months, duration of therapeutic effect – 12 months.
Indications
Treatment for established postmenopausal osteoporosis.
Contraindications
Hypersensitivity to the components of the drug.
– Hypocalcemia.
– Severe renal impairment (creatinine clearance less than 30 ml / min).
– Pregnancy and the period of breastfeeding (lactation).
– Children under 18 years old.
Precautions:
For erosive and ulcerative lesions of the mucous membrane of the gastrointestinal tract (including a history).
– In patients with a history of dysfunction of the esophagus (such as stricture or achlasia).
Use during pregnancy and lactation
Contraindicated in pregnancy and during breastfeeding.
Composition
IN 1 tab iron dye oxide red (E 172), iron dye oxide yellow (E 172)
Dosage and administration
Recommended adult dose: 35 mg once a week.
The tablet must be taken on the same day of the week.
Absorption of risedronic acid depends on the meal, therefore, to ensure adequate absorption, patients should take RIZENDROS at least 30 minutes before the first meal, another drug or drink (other than water).
It is necessary for patients to explain that if they missed a dose, then it is necessary to accept drug on that day when they remembered about it. Then the patient should return to taking one tablet once a week on the day of normal administration.
Do not take two tablets on the same day.
The tablet should be taken whole and not chewed, it is better to stand and drink it with plain water (> 120 ml). After taking the pill, patients should not go to bed for 30 minutes.
Bo During treatment, an adequate diet with sufficient calcium and vitamin D is recommended. If necessary, additional calcium and vitamin D preparations are possible.
Side effects of the
From the digestive system: often – dyspepsia, nausea, gastralgia, abdominal pain, constipation, diarrhea sometimes – esophagitis, esophageal and gastric ulcers, gastritis, colitis, dysphagia, belching, duodenitis, glossitis, glossitis, indicators of liver function.
From the nervous system: headache, dizziness, asthenia, fatigue, cramps of the calf muscles, myasthenia gravis.
From the musculoskeletal system: musculoskeletal pain, spasms of the calf muscles.
On the part of the sensory organs: acute iritis (scleral hyperemia, pain in the eyes), amblyopia, blurred visual perception, dry mucous membrane of the eyes, ringing in the ears.
Allergic reactions: skin rash.
Other: bone pain, arthralgia, bronchitis (cough), sinusitis, chest pain, peripheral edema, minor transient hypocalcemia and hypophosphatemia.
Drug Interaction
Medicines containing polyvalent cations such as calcium, magnesium, iron and aluminum can reduce the absorption of the drug.
absent Clinical znachym e interaction with nesteroydn my protyvovospalyteln my drugs (including with atsetylsalytsylovoy kyslotoy), H 2 blockers -hystamynov h receptors, proton pump inhibitors, antatsydn mylekarstvenn my funds, medlenn h kaltsyev h channels blockers, beta-blockers, diuretics tyazydn my, hlyukokortykosteroydamy, anticoagulants, protyvosudorozhn my lekarstvenn my by means of cardiac glycosides.
Compatible with hormone replacement drugs.
Overdose
Symptoms (potentially possible): Hypocalcaemia.
– Treatment: milk intake, administration of antacids containing magnesium, calcium or aluminum. In case of significant overdose, it is recommended to wash the stomach to remove unabsorbed drug.
Storage conditions
Does not require special storage conditions.
– Keep out of the reach of children.
– Do not use after the expiration date.
Expiration
2 years.
Deystvuyuschee substances
Ryzendronovaya acid
Dosage form
Dosage form
tablets
Zentiva ks, Czech Republic
