Description
Pharmacological action
Pharmacological group: hormones and their antagonists. Aglepriston, which is part of Alizin ®, is a synthetic steroid that is an antagonist of progesterone. Aglepriston blocks progesterone receptors in the uterus, disrupting the normal physiological process of maintaining pregnancy in bitches, which leads to abortion or fetal resorption. The ability of aglepristone to bind to progesterone uterine receptors in dogs is 3 times higher than for progesterone. Aglepriston does not change the concentration of progesterone, prostaglandins, oxytocin or cortisol in the blood plasma within 24 hours after its administration, however, it promotes the release of prolactin within 12 hours after injection. The maximum concentration of aglepristone is observed in the blood 2.5 days after the administration of the drug. Aglepriston bio is transformed in the liver and excreted mainly with feces.
Indications
Used to terminate an unwanted pregnancy in domestic animals up to 45 days after accidental mating. Alizine is also used to treat pyometers in dogs and cats without surgery.
Contraindications
Individual hypersensitivity to aglepriston. The drug is prohibited for dogs with impaired liver, kidney and adrenal function, as well as patients with diabetes.
Composition
As an active ingredient, 1 ml of the preparation contains 30 mg of aglepristone, as excipients – ethanol 0, 1 ml and peanut butter up to 1 ml.
Dosage and administration
Alizine is used after estrus. The drug is administered to dogs under strictly aseptic conditions, subcutaneously in the withers, twice, with an interval of 24 hours at a dose of 10 mg / kg of animal weight (0.33 ml of solution per 1 kg of animal weight). For cats, the drug is administered at a dose of 10 mg / kg of weight once every 24 hours.
Doses of Alisin, in excess of 5 ml, should be administered at different points.
Duration of administration: dogs – 0-45 days old, cats – 7-8 days after mating.
The effectiveness of the drug is 99% (when used before the 25th day) and 96% (when used until the 45th day).
The dose of the drug depending on the weight of the animal is:
Dog weight, kg
3
6
9
12
24
30
42
Dose, ml
1
2
4
4
4 srdlp the introduction of the drug, it is necessary to massage the injection site slightly. If the volume of the injected solution exceeds 5 ml, then the drug must be administered at several points. Abortion (or fetal resorption) occurs within 7 days after the administration of Alizin.
After use, a follow-up visit is required to examine and confirm abortion by ultrasound. In case of early termination of pregnancy – 20 days after treatment, on average – after 8 days. In case of incomplete abortion, treatment (2 injections of Alizin at a dose of 0.33 ml / kg / day with an interval of 24 hours) can be repeated after 10 days, between 30 and 45 days of pregnancy.
After the use of the drug, subsequent estruses pass in accordance with the physiological norm, which ensures unhindered pregnancy and childbirth.
Side effects
Allergic reactions are possible with increased individual sensitivity in animals. With the introduction of Alizin, local inflammation and pain at the injection site may occur. In bitches treated after the twentieth day of pregnancy, abortion may be accompanied by signs of a physiological birth, that is, expulsion of the fetus, a slight loss of appetite and stagnation of milk.
Storage conditions
Alizin® is stored in the manufacturer s sealed packaging, in a dry, dark place, inaccessible to children and animals, separately from food and feed at a temperature of 15 ° C to 25 ° C.
Shelf life
Shelf life of the drug, subject to storage conditions – 3 years from the date of manufacture. After the first opening of the vial, the drug can be used for no more than 28 days, subject to aseptic rules and storage at a temperature of 3 ° C to 5 ° C.
Active ingredient
Aglepriston
