Description
Pharmacological action
Amoxicillin is a semi-synthetic antibiotic from the penicillin group. It has a wide spectrum of bactericidal action against gram-positive (staphylococci, streptococci, clostridia, listeria, corynebacteria, actinomycetes) and gram-negative (bordetella, escherichia, fusobacteria, salmonella, pasteurella, hemophilus, and Proteus morbus organisms, and also leptorismos. Amoxicillin interferes with the synthesis of the bacterial cell septum, inhibiting the enzymes of transpeptidase and carboxypeptidase and causing a violation of the osmotic balance, which leads to the death of bacteria at the growth stage. With parenteral administration, amoxicillin is well absorbed into the blood from the injection site and is rapidly distributed in the body. The maximum concentration in blood plasma is reached after 1 – 2 hours after administration of the drug and remains at the therapeutic level for 48 – 72 hours. Amoxicillin is practically not metabolized. It is excreted mainly in the urine, to a lesser extent with milk and bile.
Indications
Assign to cattle, sheep, pigs, dogs and cats for the treatment of pneumonia and other respiratory diseases, enteritis and gastroenteritis, urogenital infections, atrophic rhinitis, leptospirosis and other diseases caused by microorganisms sensitive to ammazicillin.
Contraindications
Hypersensitivity to amoxicillin and other penicillins. It is forbidden to enter intravenously. Not allowed to use rabbits, hamsters, guinea pigs and gerbils. Amoxicillin should not be mixed with other drugs in the same syringe, nor can it be used simultaneously with bacteriostatic chemotherapeutic agents. The drug should not be prescribed for infections caused by bacteria that form penicillinase.
Special instructions
Slaughter of animals for meat is allowed 14 days after discontinuation of the drug. The meat of animals forced to be killed before the expiration of this period can be used to feed fur animals or produce meat and bone meal. Milk from animals that were injected with a suspension of Amoxoyl retard is allowed to be used for food purposes after 48 hours after the end of treatment. Milk obtained from animals during the use of amoxicillin and until 48 hours after the last injection of the drug is used to feed animals.
Composition
Long-acting antibacterial preparation containing 150 mg of amoxicillin trihydrate and an excipient in 1 ml of active ingredient.
Dosage and administration
Amoxoyl retard is administered to animals intramuscularly or subcutaneously at a dose of 1 ml per 10 kg of animal weight. If necessary, re-administration of the drug after 48 hours is possible. For animals with renal failure, it is recommended to accurately calibrate the dose of the drug. Before use, the contents of the vial are thoroughly shaken until a homogeneous suspension is obtained. Only sterile dry syringes and needles are used to administer Amoxoyl retard suspension. If the administered dose of the drug exceeds 20 ml, it is recommended to administer it with several injections at different points. The injection site after administration of Amoxoyl retard is recommended to massage slightly.
Side effects of
In animals, allergic reactions to amoxicillin are possible, which quickly disappear after discontinuation of the drug. Intoxication due to overdose is almost impossible. If allergic reactions occur, it is advisable to administer to animals corticosteroids and adrenaline.
