Description
Latin name
GANFORT
Release form
eye drops.
Packaging
In a plastic dropper bottle 3 ml of solution. In the package 1 bottle.
Indications
Decreased intraocular pressure (IOP) in patients with open-angle glaucoma and intraocular hypertension with insufficient effectiveness of topical use of beta-blockers and prostaglandin analogues.
Use during pregnancy and lactation
Contraindicated.
Composition
1 ml solution of eye drops contains:
Active ingredient
Bimatoprost 0.3 mg.
timolol maleate 6.8 mg. In terms of timolol 5.0 mg.
Excipients
Benzalkonium chloride, citric acid monohydrate, sodium hydrogen phosphate heptahydrate, sodium chloride, hydrochloric acid, sodium hydroxide, water.
Dosage and administration
Recommended doses in adults (including elderly patients): 1 drop is instilled into the conjunctival sac of the affected eye 1 time per day in the morning.
If administration of the drug is skipped once, the drug is administered the next day. It is not recommended to exceed a dose of 1 introduction 1 time per day. If you use more than 2 drugs, you must take a 5-minute break between each instillation.
Side effects of
The frequency of side effects identified during the studies was estimated as follows:
Very often (> 1/10).
Often (> 1/100,
Infrequently (> 1/1000,
) In clinical trials of Ganfort, the following side effects were identified:
Central nervous system
Infrequent headache.
Visual organ
Very often conjunctival hyperemia , eyelash growth
Often – superficial keratitis, erosion of the cornea, burning sensation, itching, burning pain in the eyes, sensation of a foreign body, dry mucous membrane of the eyes, redness of the eyelids, pain in the eyes, photophobia, discharge from the eyes, visual impairment, itching of the skin century.
Infrequently – iridocyclitis, irritation of the mucous membrane of the eyes, conjunctival edema, blepharitis, epiphora, swelling of the eyelids, sore eyes, decreased visual acuity, asthenopia, trichiasis.
Frequency unknown – cystoid macular edema.
From the respiratory system
Uncommon – rhinitis.
From the skin and subcutaneous fat
Often – pigmentation of the skin of the eyelids.
Infrequently – hirsutism.
Other side effects that were observed when using one of the components of the drug and potentially possible during the treatment with Ganfort:
Bimatoprost
Infectious and parasitic diseases
Infectious disease (catarrhal symptoms and upper respiratory tract infection).
From the nervous system
Dizziness.
On the part of the organ of vision
Allergic conjunctivitis, cataracts, darkening of the eyelashes, increased pigmentation of the iris, blepharospasm, eyelid retraction, retinal hemorrhage, uveitis.
From the cardiovascular system
Increased blood pressure.
General disorders and changes in the injection site
Asthenization neuropsychic, peripheral edema.
Laboratory findings
Changes in liver enzyme activity.
timolol
Mental disorders
Insomnia, nightmares, decreased libido.
From the central nervous system
Myasthenia gravis, paresthesia, cerebral ischemia.
On the part of the organ of vision
Decreased sensitivity of the cornea, diplopia, ptosis, retinal detachment (after surgical treatment), change in refraction (due to cancellation of therapy with miotic drugs in some cases), keratitis.
On the part of the organ of hearing and the vestibular apparatus
Tinnitus.
From the cardiovascular system
Heart block, cardiac arrest, cardiac arrhythmias, loss of consciousness, bradycardia, heart failure, congestive heart failure, decreased blood pressure, chest pain, cerebrovascular accident, intermittent claudication, Raynaud’s syndrome, cold extremities heartbeat.
From the respiratory system
Bronchospasm (mainly in patients with a history of bronchospasm), shortness of breath, cough.
From the gastrointestinal tract
Nausea, diarrhea, dyspepsia, dry oral mucosa.
On the part of the skin and subcutaneous fat
Alopecia, psoriasis-like rashes, exacerbation of psoriasis.
From the musculoskeletal system and connective tissue
Systemic lupus erythematosus.
From the urinary system
Peyronie’s disease.
Other
Edema, chest pain, fatigue.
Overdose
No cases of overdose with the drug Hanfort were reported with the introduction of eye drops, an overdose is unlikely.
Bimatoprost
The following information may be useful when inadvertently taking the drug Ganfort – no symptoms of toxic effects of bimatoprost at doses up to 100 mg / kg / day during 2-week oral administration in rats and mice were observed. The dose used in the study, expressed in mg / m 2, exceeds 70 times the possible dose of bimatoprost if accidentally taken inside the contents of the vial of the drug Ganfort child with a body weight of 10 kg.
Timolol
Symptoms of an overdose of timolol can be observed in the following: bradycardia, decrease in blood pressure, bronchospasm, headache, dizziness, shortness of breath, cardiac arrest.
Treatment: carrying out symptomatic therapy. Studies have shown that timolol is not completely excreted in hemodialysis.
Storage Conditions
At a temperature not exceeding 25 ° C. Keep out of reach of children.
Shelf life
2 years. The shelf life of the drug after the first opening of the bottle is 28 days.
Active substance
Betamethasone, Timolol
otpuska IZ
pharmacy prescription
Dosage
eye drops
Possible product names
GANFORT 0,0003 / ML + 0,005 / ML 3ML N1 FLAC / KAP GL GL CAP
GANFORT 0,3 + 5MG / ML. 3ML. CHAPTER DROPS FL. / CAP.
Ganfort 0.3mg / ml + 5mg / ml eye drops 3ml Flood-cap / e X1
Ganfort 3ml gl drops
Ganfort eye drops 0.3mg + 5mg / ml 3ml
Allergan, United States
