Description
Release form
Chewable tablets (lemon)
Packing
120 pieces.
Pharmacological action
Pharmacodynamics
Regulates the exchange of calcium and phosphorus in the body (bones, teeth, nails, hair, muscles). Reduces resorption (resorption) and increases bone density, making up for the lack of calcium and vitamin D3 in the body, necessary for mineralization of the teeth.
Calcium is involved in the regulation of nerve conduction, muscle contractions and is a component of the blood coagulation system.
Vitamin D3 increases intestinal absorption of calcium.
The use of calcium and vitamin D3 prevents the increase in the production of parathyroid hormone (PTH), which is a stimulator of increased bone resorption (leaching of calcium from bones).
Pharmacokinetics
Calcium
Absorption. Typically, the amount of calcium absorbed in the gastrointestinal tract is approximately 30% of the dose taken.
Distribution and metabolism. 99% of the calcium in the body is concentrated in the rigid structure of bones and teeth. The remaining 1% is in intracellular and extracellular fluids. About 50% of the total calcium in the blood is in physiologically active ionized form, of which about 10% are in complex with citrate, phosphate or other anions, the remaining 40% are associated with proteins, primarily with albumin.
Withdrawal. Calcium is excreted by the intestines, kidneys and sweat glands. Renal excretion depends on glomerular filtration and tubular calcium reabsorption.
Vitamin D3
Suction. Vitamin D3 is easily absorbed in the small intestine (about 80% of the dose taken).
Distribution and metabolism. Colecalciferol and its metabolites circulate in the blood, associated with specific globulin. Colecalciferol is converted in the liver by hydroxylation to 25-hydroxycolcalciferol. Then converted in the kidneys into active form 1, 25-hydroxycolcalcaliferol. 1,25-hydroxycolcalcaliferol is a metabolite responsible for increasing calcium absorption. Non-metabolized vitamin D3 is deposited in adipose and muscle tissue.
Withdrawal. Vitamin D3 is excreted by the intestines and kidneys.
Indications
Prevention and treatment of calcium and / or vitamin D3 deficiency
Prevention and treatment of osteoporosis (menopausal, senile, steroid, idiopathic).
Contraindications
Hypersensitivity to the components of the drug
Hypercalcemia, hypercalciuria
Nephrolithiasis
Vitamin D hypervitaminosis
Severe renal insufficiency
Recurrent tuberculosis 3 years.
Caution: Pregnancy is a lactation period.
Use during pregnancy and lactation
The daily dose should not exceed 1500 mg of calcium and 600 IU of vitamin D3.
Hypercalcemia that develops with an overdose during pregnancy, may cause defects in the mental and physical development of the child.
Vitamin D and its metabolites can pass into breast milk, so you must consider the intake of calcium and vitamin D from other sources in the mother and baby.
Composition of
1 tablet contains:
Calcium carbonate 1250 mg (corresponding to 500 mg of calcium)
Colecalciferol (vitamin D3) 400 IU
Excipients:
Sorbitol
soml sdlmpd fatty acids.
Dosage and administration
Tablets Calcium-D3 Nycomed forte are taken orally, chewing or resorbing, during meals
Treatment of osteoporosis: adults – 1 tablet. 2 times a day in the treatment of osteoporosis – 1 tablet. 2-3 times a day.
With a deficiency of calcium and vitamin D: adults and children over 12 years old – 1 tablet. 2 times a day for children from 3 to 12 years old – 1 table. in a day.
Side effects
Allergic reactions
Gastrointestinal dysfunction (constipation or diarrhea, flatulence, nausea, abdominal pain)
Hypercalcemia and hypercalciuria.
Storage conditions
In a dark place at a temperature of no higher than 25 ° C, in a tightly closed package.
Expiration
3 years.
Deystvuyuschee substances
calcium carbonate, Kolekaltsyferol
dosage form
lozenges
Indications
bronchoconstriction From infektsiy mochev vodyashtih Putten, from infektsiy d hatelyn h Putten, from vospaleniya legkih, From infektsiy skins From infectious diseases, from boils, from sinusitis, from sinusitis nutrition, From bone fractures, From osteoporosis, With menopause
Takeda Pharmaceuticals Ltd., Russia
