Description
Latin name
Solcoseryl
Release form
Gel.
Pharmacological action
Solcoseryl – antihypoxic, cytoprotective, regenerating, membrane stabilizing, angioprotective, wound healing.
Solcoseryl is a deproteinized hemodialysate containing a wide range of low molecular weight components of the cell mass and blood serum of dairy calves with a molecular weight of 5000 D, whose properties are currently only partially studied by chemical and pharmacological methods.
In vitro tests, as well as in preclinical and clinical studies, it was found that Solcoseryl: enhances reparative and regenerative processes
promotes activation of aerobic metabolic processes and oxidative phosphorylation of
increases oxygen consumption in vitro and stimulates glucose transport to cells in the conditions hypoxia and into metabolically depleted
cells increases collagen synthesis (in vitro)
stimulates cell proliferation and migration (in vitro).
Solcoseryl gel does not contain fat as auxiliary components, making it easy to rinse. Promotes the formation of granulation tissue and the elimination of exudate.
Since the appearance of fresh granulations and drying of the wound, it is recommended to use Solcoseryl ointment, which contains fats as auxiliary components and forms a protective film on the wound surface.
Pharmacokinetics
Studies on the absorption, distribution and excretion of the drug using standard pharmacokinetic methods are not possible, because the active component of the drug (deproteinized hemodialysis) has pharmacodynamic effects characteristic of molecules with different physicochemical properties.
Indications
Minor damage (abrasions, scratches, cuts).
1 and 2 degree burns (sunburn, thermal burns).
frostbite.
Hardly healing wounds (including trophic ulcers and pressure sores).
Contraindications
Hypersensitivity to one of the components of the drug.
Caution – with a predisposition to allergic reactions.
Use during pregnancy and lactation
The use of Solcoseryl, like all other drugs, is undesirable during pregnancy and lactation and is possible only if absolutely necessary and under the supervision of a doctor.
Composition of
1 g of gel contains:
Active ingredient: deproteinized dialysate from the blood of healthy dairy calves, standardized chemically and biologically (in terms of dry matter) 4.15 mg
Excipients: calcium lactate sodium carboxymethyl cellulose propylene glycol water for injection.
Dosage and administration
Apply directly to the wound surface after preliminary cleaning of the wound using a disinfectant solution.
Prior to treatment of trophic ulcers, as well as in cases of purulent infection of the wound, preliminary surgical treatment is necessary.
Solcoseryl gel is applied to fresh wounds, wounds with wet discharge, ulcers with wetting symptoms – a thin layer on a cleaned wound 2-3 times a day. Areas with epithelization that has begun are recommended to be oiled with Solcoseryl. The use of Solcoseryl gel continues until a pronounced granulation tissue forms on the damaged skin surface and the wound dries.
Side effects
In rare cases, allergic reactions can develop (urticaria, hyperemia and edema at the injection site, fever). In this case, it is necessary to stop the use of the drug and prescribe symptomatic treatment.
Drug Interactions
Saloseril injections should not be mixed with other medicinal products, especially phytoextracts.
Pharmaceutical incompatibility Solcoseril in the form of a solution for injection with parenteral forms has been established: Ginkgo biloba extract,
naphtydrofuryl,
benzyclan fumarate.
Only isotonic sodium chloride solution and 5% glucose solution should be used as solutions for dilution of Solcosyl Injection.
No interaction of Solcoseril with other topical medicinal products has been established.
Storage Conditions
In a dark place at a temperature not exceeding 25 ° C.
Deystvuyushtee substance
Deproteinizirovann y dialysate through Resurrection facturer
dosage form
gel for external use
Possible Product Names
Pangrol Caps. enteric. 25000 UNITS N20 Italy-Germany
Solcoseryl Gel 20g
Solcoseryl 10% 20g
gel SOLKOSERIL 20.0 GEL
SOLKOSERIL 20G. GEL
Meda Farma GmbH and Ko.KG, Macedonia
