Description
Pharmacological action
Pharmacodynamics
The combination of hesperidin + diosmin has venotonic and angioprotective properties.
Reduces venous distensibility and venous congestion, in microcirculation – it reduces the permeability of capillaries and increases their resistance, improves venous hemodynamics. It affects the following venous plethysmographic parameters: venous capacity, venous extensibility, time of venous emptying. The optimal effect is achieved when taking 2 tablets per day.
The combination of hesperidin + diosmin increases venous tone by reducing the time of venous emptying. In patients with signs of severe microcirculation disturbance, an increase in capillary resistance is noted after the use of the hesperidin + diosmin combination.
The combination of hesperidin + diosmin is effective in the treatment of chronic lower limb vein diseases, as well as in the treatment of hemorrhoids
Pharmacokinetics
The drug Phlebaven ® is primarily excreted through the intestines. The kidneys, on average, remove about 14% of the dose taken.
The elimination half-life is 11 hours.
The drug undergoes an active metabolism, which is confirmed by the presence of phenolic acids in the urine.
Indications
The drug Phlebaven ® is indicated for the treatment of symptoms of chronic venous diseases (elimination and relief of symptoms)
Therapy for symptoms of venous-lymphatic insufficiency:
pain
cramps of the lower extremities
feeling of heaviness and fullness in legs srdlkk legs tiredness .
Therapy for manifestations of venous-lymphatic insufficiency:
edema of the lower extremities
trophic changes in the skin and subcutaneous tissue
venous trophic ulcers.
Symptomatic therapy of acute and chronic hemorrhoids.
Contraindications
Hypersensitivity to the active or auxiliary substances that make up the drug.
It is not recommended to take the drug during breastfeeding.
Pregnancy and lactation
Pregnancy
Animal experiments have not revealed teratogenic effects.
To date, there have been no reports of adverse effects when using the drug in pregnant women.
Breastfeeding period
Due to the lack of data on the excretion of the drug with breast milk, women are not recommended to take the drug during the period of breastfeeding.
Impact on reproductive function Reproductive toxicity studies have not shown an effect on reproductive function in rats of either sex.
Special instructions
It is recommended that you consult a doctor before taking Phlebaven ®.
With exacerbation of hemorrhoids, the use of the drug Flebaven ® does not replace the specific treatment of other anal disorders. The duration of treatment should not exceed the time specified in the section “Method of application and dose.” In the event that the symptoms do not disappear after the recommended course of therapy, an examination by a proctologist should be performed, who will select further therapy.
In the presence of impaired venous circulation, the maximum treatment effect is ensured by a combination of therapy with a healthy (balanced) lifestyle: it is advisable to avoid long exposure to the sun, prolonged stay on the legs, and it is recommended to reduce excess body weight. Hiking and, in some cases, Wearing special stockings helps to improve blood circulation.
Seek medical attention immediately if your condition worsens during treatment or if there is no improvement.
Effect on the ability to drive vehicles,
mechanisms Does not affect
Composition
For 1 tablet:
Core:
Purified micronized flavonoid fraction, substance – granules 613.00 mg
Active substance substance – granular granular: granular diosmin (90%) 450 mg, flavonoids in terms of hesperidin (10%) 50 mg] 500.00 mg
Excipients substances – granules:
Microcrystalline cellulose,
Povidone K-30]
Excipients:
carboxymethyl starch sodium
Talc
Magnesium stearate
Shell Film:
Opadry orange 03N3259911 comprising:
hypromellose dioxide (E171) titanium
talc
propylene
dye yellow iron oxide (E172)
iron colorant oxide red (E172)
Dosage and Administration
Inside.
The recommended dose for venous-lymphatic insufficiency is 2 tablets per day (in one or two doses): in the morning, afternoon and / or evening, during meals.
The duration of treatment can be several months (up to 12 months). In case of recurrence of symptoms, on the recommendation of a doctor, the course of treatment can be repeated.
The recommended dose for acute hemorrhoids is 6 tablets per day: 3 tablets in the morning and 3 tablets in the evening for 4 days, then 4 tablets per day: 2 tablets in the morning and 2 tablets in the evening for the next 3 days.
The recommended dose for chronic hemorrhoids is 2 tablets per day.
Side effects of
side effects of the hesperidin + diosmin combination observed in clinical trials were mild. Mostly, disorders of the gastrointestinal tract (diarrhea, dyspepsia, nausea, vomiting) were noted.
World Health Organization (WHO) recommended classification of side effects:
very common:? 1/10
often: from? 1/100 to <1/10 infrequently: from? 1/1000 to <1/100 rare: from? 1/10000 to <1/1000 is very rare: <1/10000 frequency is unknown: cannot be estimated based on available data. From the central nervous system: rarely: dizziness, headache, general malaise From the digestive system: often: diarrhea, dyspepsia, nausea, vomiting infrequently: pricks frequency is unknown: abdominal pain from the skin: is rare: skin rash, sore skin itching, sore lash, isolated swelling of the face, lips, eyelids. In exceptional cases, angioedema INFORM YOUR DOCTOR ABOUT YOURSELF, INCLUDING ANY UNPOSED REACTIONS AND FEELINGS IN THESE INSTRUCTIONS, ALSO ABOUT CHANGING ANYTHING. Drug Interactions Not observed. Overdose Overdose cases not described. If you overdose with Flebaven ®, seek medical attention immediately. Storage conditions At a temperature not exceeding 25 ° C, in the original packaging. Keep out of the reach of children. Expiration 2 years. Deystvuyuschee substances diosmin pharmacies terms and conditions without a prescription Form of Treatment tablets Appointment Vzrosl m , Pregnant doctor
