Description
Latin name
Ocumethyl
Release form
Okumet. Eye drops.
Packaging
In a dropper bottle 10 ml of solution. In the package 1 bottle.
Pharmacological action
Okumetil is a combined preparation containing zinc sulfate, diphenhydramine inazolin.
Zinc sulfate when applied topically has an astringent, drying, anti-inflammatory and antiseptic effect.
Naphazoline is a sympathomimetic. It has a rapid, pronounced and prolonged vasoconstrictor effect. When applied topically, it reduces swelling and hyperemia of the mucous membranes.
Diphenhydramine is a blocker of H1-histamine receptors. When applied topically, it reduces the permeability of capillaries and prevents tissue swelling.
Thus, Okumetil has an antiseptic, anti-allergic and anti-inflammatory effect.
Pharmacokinetics
When applied topically, it undergoes systemic absorption. There is no information on the degree of penetration into various tissues of the eye after topical application.
Indications
Chronic non-specific conjunctivitis and blepharoconjunctivitis.
Allergic conjunctivitis and blepharoconjunctivitis.
Angular conjunctivitis.
Reducing symptoms of eye tissue irritation (redness, itching, foreign body sensation).
Contraindications
Hypersensitivity to the components of the drug.
Angle-closure glaucoma.
Dry Eye Syndrome.
Pregnancy.
Lactation.
Prostate hyperplasia.
Stenotic ulcer of the stomach and duodenum.
Stenosis of the neck of the bladder.
Bronchial asthma.
epilepsy.
Cardiovascular disease (CHD, arterial hypertension).
Pheochromocytoma.
Hyperthyroidism.
Diabetes mellitus.
Severe atherosclerosis.
Children’s age up to 2 years.
Use with caution in patients taking MAO inhibitors or other drugs that increase blood pressure.
Use during pregnancy and lactation
Contraindicated in pregnancy and during lactation.
Composition
10 ml solution:
Active substances:
zinc sulphate – 10 mg
diphenhydramine hydrochloride – 10 mg
naphazoline hydrochloride – 10 mg
Excipients:
sodium citrate,
citric acid,
benzalkonium chloride,
sodium srdlp sodium hydroxide, sbrlkp dye srldlp sodium hydrochloride srldlp srldlp srldlp srldlp sodium hydroxyp ,
distilled water.
Dosage and Administration
Topically.
Unless otherwise prescribed by a doctor, then instill 1 drop in the conjunctival sac of the affected eye (s) 2-3 times a day.
If during the use of the drug within 72 hours there is no decrease in symptoms, you should stop using the drug and consult a doctor.
Side effects
After instillation, a slight burning sensation, blurred vision, the development of allergic reactions may occur.
In aphakia, the development of maculopathy and the appearance of a central scotoma are possible. In this case, the withdrawal of the drug leads to the reverse development of symptoms.
After topical use of naphazoline, which is part of Okumethyl, reactive hyperemia and swelling of the mucous membrane of the eyes, pupil expansion, and increased IOP (intraocular pressure) may occur.
With prolonged use, tissue irritation occurs most frequently.
Since topical application of naphazoline has a general resorptive effect, it is possible to develop tachycardia, increased blood pressure, nausea, and headache.
With topical administration of diphenhydramine, side effects of both local and systemic nature of paresis of accommodation may develop, photosensitivity, dryness and numbness of the mucous membrane of the eyes, drowsiness, weakness, decreased psychomotor reactions and impaired coordination of movements, dizziness.
With prolonged use of zinc salts, dryness of the mucous membrane of the eyes may occur.
Drug Interaction
As it is possible to reduce the effects of diphenhydramine and drugs that stimulate the central nervous system, the use of the drug Okumetil in patients using these drugs is not recommended.
Okumetil should not be used concomitantly with MAO inhibitors and for 10 days after discontinuation.
As a result of the joint use of beta-blockers, MAO inhibitors with adrenomimetics, the action of the latter is enhanced.
Nafazoline slows down the absorption of topical anesthetics, so it is not recommended to co-administer the drug Okumetil with topical anesthetics used in ophthalmology.
Zinc sulfate is not pharmaceutically compatible with salts of silver, lead, quinine, ichthyol, citral, protargol, alkali-reactive substances.
Terms of storage
Keep protected from light, out of reach of children at a temperature of 15-25 ° C.
Shelf life
3 years. After opening the bottle should be used within 1 month.
Conditions of Release from drugstores
Without Prescription
dosage form
eye drops
Possible product names
MADE 10ML GL DROPS FLAK / KAP
Okumel 10ml hl. drops M
Okumetil 10ml hl. drops
DID 10ML. CHAPTER DROPS
DESCRIPTED CH. DROPS FL.-DROPS. 10ML
Alexandria, Egypt
