Description
Latin name
FAMOTIDIN
Release form
Film-coated tablets.
Packing
30 pcs
Pharmacological action
Famotidine has an antiulcer effect. Blocker of H2-histamine receptors of the III generation. Suppresses basal and stimulated by histamine, gastrin and acetylcholine production of hydrochloric acid. Reduces pepsin activity. It enhances the protective mechanisms of the gastric mucosa, promotes the healing of damage associated with the action of hydrochloric acid (including scarring of stress ulcers) and the cessation of gastrointestinal bleeding by increasing the formation of gastric mucus, its glycoproteins, and stimulating the secretion of bicarbonate by the gastric mucosa, endogenous synthesis of prostaglandins in it and the rate of regeneration. Does not significantly change the level of gastrin in plasma. Weakly inhibits the oxidase system of cytochrome P450 in the liver.
After oral administration, the action begins after 1 hour, reaches a maximum within 3 hours. The duration of the drug with a single dose depends on the dose and ranges from 12 to 24 hours.
Indications
Peptic ulcer and duodenal ulcer (including the prevention of exacerbations)
symptomatic ulcers, erosive and reflux esophagitis
Zollinger-Ellison syndrome.
Contraindications
Hypersensitivity, pregnancy, lactation.
Special instructions
Before treatment, it is necessary to exclude the presence of a malignant process in the digestive tract.
Ingredients
1 tablet: 20 mg microcrystalline cellulose, silicon dioxide, talc, magnesium stearate, croscarmellose sodium
Shell composition: hypromellose, macrogol 6000, titanium dioxide (E171), talc, iron dye oxide The brown.
Dosage and administration
Inside, swallowing whole (without chewing), drinking plenty of water. With peptic ulcer of the stomach and duodenum in the acute phase, symptomatic ulcers, erosive gastroduodenitis – usually 20 mg 2 times a day or 40 mg once a day at night. If necessary, the daily dose can be increased to 80-160 mg. The course of treatment is 4-8 weeks.
With dyspepsia associated with increased secretory function of the stomach, 20 mg 1-2 times a day.
In order to prevent recurrence of peptic ulcer disease – 20 mg once a day at bedtime.
For reflux esophagitis, 20 40 mg 2 times a day for 6 12 weeks.
With Zollinger-Ellison syndrome, the dose of the drug and the duration of the course of treatment are set individually. The initial dose is usually 20 mg every 6 hours and may be increased to 160 mg every 6 hours.
For the prevention of aspiration of gastric juice with general anesthesia, 40 mg in the evening and / or in the morning before surgery.
In case of renal failure (with Cl creatinine 3 mg / 100 ml), the daily dose should be reduced to 20 mg.
Side effects
Rarely – headache, dizziness, fatigue, dry mouth, lack of appetite, diarrhea or constipation, skin rash.
Drug interactions
Antacids interfere with absorption (recommended a break between antacids and famotidine for at least 1 2 hours).
Storage conditions
Store at 15 to 25 ° C.
Expiration
3 years.
active substance
Famotidine
Terms leave through pharmacies
In retseptu
PMA pills
