Description
Latin name
Ketonal DUO
Release form
Modified-release capsules
packaging 30 pcs
Pharmacological action
Ketonal – NSAIDs, a derivative of propionic acid.
It has analgesic, anti-inflammatory and antipyretic effects.
The mechanism of action is associated with inhibition of prostaglandin synthesis at the level of cyclooxygenase.
In addition, ketoprofen inhibits lipoxygenase, has anti-bradykinin activity, stabilizes lysosomal membranes, and significantly inhibits neutrophil activity in patients with rheumatoid arthritis.
The pronounced analgesic effect of ketoprofen is due to two mechanisms: peripheral (indirectly, through suppression of prostaglandin synthesis) and central (due to inhibition of prostaglandin synthesis in the central and peripheral nervous system).
Indications
Symptomatic therapy of painful inflammatory processes of various genesis (including postoperative and post-traumatic pains, sciatica, myalgia, radiculitis, bruises and muscle sprains, rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, acute attack, poditrosis, bursitis).
Contraindications
gastrointestinal tract disease in the exacerbation phase
severe liver dysfunction
severe renal dysfunction
blood disorders (leukopenia, thrombocytopenia, blood coagulation system disorders) I
children who are suffering from srdlcp hypersensitivity to ketoprofen, acetylsalicylic acid or other NSAIDs (history of bronchospasm, urticaria and rhinitis, caused by acetylsalicylic acid).
Use during pregnancy and lactation
The use of Ketonal in the third trimester of pregnancy is contraindicated.
The use of Ketonal in the first and second trimesters of pregnancy is possible only if the potential benefit to the mother outweighs the risk to the fetus.
If you need to use Ketonal during lactation, you should decide on the termination of breastfeeding.
Composition
1 caps. contains ketoprofen 150 mg
Dosage and administration of
Adults: 1-2 caps. 2-3 times / day, or 1 tab. 2 times / day, or 1 tab. prolonged action 1 time / day.
Capsules and tablets should be taken during or immediately after a meal, without chewing, drinking plenty of water or milk (liquid volume – at least 100 ml).
Oral forms can be combined with the use of rectal suppositories or dosage forms of Ketonal for external use (cream, gel).
Maximum daily dose (including when using various dosage forms) is 200 mg.
Overdose
Symptoms: nausea, vomiting, abdominal pain, vomiting with blood, melena, impaired consciousness, respiratory depression, convulsions, impaired renal function, renal failure.
Treatment: gastric lavage, the appointment of activated carbon, conduct symptomatic therapy.
The use of histamine H 2 receptor blockers, proton pump inhibitors, and prostaglandin inhibitors has been shown. There is no specific antidote.
Storage conditions
In the dark place at a temperature of no higher than 25 ° C.
Expiration
5 years.
The active substance
Ketoprofen
Dosage form
dosage form
prolonged-action capsules
