Description
Pharmacological action of
The mechanism of action of megestrol acetate consists in acting on the hypothalamic-pituitary system, blocking the secretion of gonadotropin hormones (FSH and LH) by the adenohypophysis. A decrease in the level of gonadotropic hormones in the blood leads to a violation of folliculogenesis in females, as a result of which follicles do not mature and ovulate, inhibit cell hyperplasia and secretion of the mammary gland. A decrease in the level of gonadotropic hormones in the blood suppresses hormone-dependent neoplasms. The use of the drug leads to a decrease in testosterone levels in the body of males and cats and estrogen in the body of bitches and cats and, as a result, inhibition of sexual hunting. When the drug is canceled, the concentration of megestrol acetate in the body decreases, the normal level of LH and FSH in the blood of the animal is restored, the contraceptive effect of the drug stops and the reproductive cycle is restored.
Indications
Four with a tail drops for regulating sexual hunting and pills are used for females and cats to delay and interrupt estrus, as well as for males and cats to reduce sexual activity and correct behavior.
Contraindications
The use of drugs is contraindicated: for females and cats from 3 days from the onset of estrus, immature, pregnant and lactating animals, as well as animals of both sexes with diseases of the reproductive system, breast tumors, diabetes mellitus, hormonal disorders and individual hypersensitivity to components the drug.
Composition
Four with a tail tablets in 1 tablet contains acetate – 5 mg as the active substance of megestrol.
Dosage and administration
“Four with a tail” drops for regulation of sexual hunting and tablets are used in animals, individually 1-2 hours before feeding, forcibly to the root of the tongue or with a treat according to the specified scheme. Cats are prescribed ² ÑFour with a tail ² Ñ drops for regulating sexual hunting in cats and tablets according to the following scheme (table 1):
Purpose of giving
preparation Duration Form
preparation Dose
preparation Duration
for
interruption
estrus
no later than
3 days after
started
estrus
drops daily,
6 drops
(0.3 ml) for 8 days
tablets daily,
1 tablet for 8 days
for
delay
estrus
start
start
start
start
Drops of 6 drops
(0, 3 ml) 1 time
in 2 weeks no more than 18
months
Tablets 1 tablet
once in
2 weeks no more than 18
months
Before starting a new course of use, it is recommended to take a break for at least 2 months. Repetition of the course is possible after a normal physiological reproductive cycle appears in a cat. In case of difficulty in determining the onset of estrus, it is recommended that it be delayed rather than interrupted.
Bitches, depending on body weight, are prescribed ² ÑFour with a tail ² Ñ drops for regulation of sexual hunting and pills according to the following scheme:
² Ñ to delay estrus, the drug is given 7-15 days before estrus. Dosage taking into account the weight of the animal is presented in table 2. The duration of use depends on the desired period of delay in estrus, but not more than 32 days. The estrus may begin a few days after the cessation of the drug. With prolonged use of the drug (about a month), estrus usually begins after 4-6, sometimes after 2-9 months.
Table 2
Dosage “Four with a tail” drops for regulation of sexual hunting in order to delay estrus in bitches depending on the weight of the animal.
Animal weight, kg
Daily dose of megestrol acetate, mg
Daily dose
Daily dose, tablets
drops
ml
Up to 5
2.5
3 5
5,5
6 0,5
0.25
1
11-15
7.5
8
0.4
1.5
16-20
10
10
0.5
2
21-30
15
15 srd
3
31-40
20
20
1
4
41-50
25
25
1, 25
5
51-60
30
30
1,5
6
² Ñ give an interruption to estrus when its first signs appear (no later than 3 days after its onset). The dosage taking into account the weight of the animal is presented in Table 3. During the first three days of the course, give a daily dose, then during the next seven days, half the daily dose. After the cessation of giving means, estrus usually begins after 4-6, sometimes after 2-9 months.
Table 3
Dosage ² ÑFour with a tail ² Ñ drops for regulating sexual hunting in order to interrupt estrus in bitches depending on the weight of the animal.
Animal weight, kg
Daily dose of megestrol acetate, mg
Daily dose of the drug
Daily dose, tablets
drops
ml
Up to 5
10
10
0, 5
2
6-10
20
20
1
4
11-15
30
30
1.5
6
16-20
40
40
2 srd 60p srd 60 srd 3
12
31-40
80
80
4
16
41-50
100
100
5
20
51-60
120
120
2 srdl recommended year.
For males, to reduce sexual activity and correct behavior, the drug is used in the following doses: ² Ñ for cats, 1 tablet per animal daily for 5-7 days, then 1 time per week until
behavior correction is achieved ² Ñ for males, 1 tablet per 2.5 kg of animal weight daily for the first 7 days, the next 14 days – half the daily dose.
Side effects
When applying the “Four with a tail” drops to regulate sexual hunting and tablets in accordance with the instructions side effects and complications, as a rule, is not observed. In rare cases, an increase in body weight is possible, as well as the appearance of slight depression or aggressiveness.
In case of an overdose, the development of pathological changes in the tissues of the uterus and ovaries, a slight increase in the mass of the animal, an increase in appetite, lethargy, and slight hypertrophy of the mammary glands are possible.
Storage conditions
Store the drug in the manufacturer’s sealed packaging, at a temperature of 2 ° C to 25 ° C.
Expiration
3 years.
active substance
Megestrol
