Description
Release form
Solution for intravenous and intramuscular administration.
Packing
5 pcs.
Pharmacological action
Cycloferon – Antiviral and immunomodulating drug. Inducer of interferon synthesis.
The main producing cells of interferon after Cycloferon administration are macrophages, T-lymphocytes, B-lymphocytes, fibroblasts, epithelial cells. Depending on the type of infection, one or another link in the immune system is activated. The drug induces high titers of interferon in organs and tissues containing lymphoid elements (spleen, liver, lungs), activates bone marrow stem cells, stimulating the formation of granulocytes. Cycloferon activates T-lymphocytes and natural killer cells, normalizes the balance between subpopulations of T-helpers and T-suppressors. Overcomes the blood-brain barrier.
Cycloferon is effective against tick-borne encephalitis, influenza, hepatitis, herpes, cytomegalovirus, human immunodeficiency virus, papilloma virus and other viruses.
The drug has been found to be highly effective in the complex treatment of acute and chronic bacterial infections (chlamydia, erysipelas, bronchitis, pneumonia, postoperative complications, bacterial and fungal infections of the genitourinary tract, peptic ulcer) as a component of immunotherapy.
Cycloferon is highly effective in rheumatic and systemic diseases of the connective tissue, suppressing autoimmune reactions and providing anti-inflammatory and analgesic effects.
The immunomodulatory effect of cycloferon is expressed in the activation of phagocytosis, natural killer cells, cytotoxic T-lymphocytes and correction of the body’s immune status in immunodeficiency and autoimmune conditions of various origins.
Indications
As part of complex therapy in adults:
– HIV infection (stages 2A-2B)
– neuroinfection: serous meningitis and encephalitis, tick-borne borreliosis (Lyme disease)
– viral hepatitis D, B, hepatitis D, B, hepatitis D, B, herpetic infection
– cytomegalovirus infection
– secondary immunodeficiencies associated with acute and chronic bacterial and fungal infections
– chlamydial infections
– rheumatic and systemic diseases of the connective tissue (rheumatoid arthritis, systemic lupus erythematosus)
– degenerative joint disease (including deforming osteoarthrosis).
As part of complex therapy in children:
– viral hepatitis A, B, C, D
– herpetic infection
– HIV infection (stages 2A-2B).
Contraindications
Pregnancy, lactation, children under 4 years of age, individual intolerance to the components of the drug, decompensated liver cirrhosis.
Use during pregnancy and lactation
Contraindicated.
Special instructions
For diseases of the thyroid gland, consultation with an endocrinologist is necessary.
Composition of
1 ampoule (2ml) contains acridonoacetic acid (in the form of meglumine acridone acetate) 250 mg
excipients: water d / u.
Dosage and administration of
Adults Cycloferon is administered i / m or iv once a day according to the basic scheme: every other day. The duration of treatment depends on the disease.
For herpetic and cytomegalovirus infections, the drug is prescribed according to the basic scheme – 10 injections of 250 mg each. The total dose of 2.5 g. Treatment is most effective at the onset of an exacerbation of the disease.
In case of neuroinfections, the drug is administered according to the basic scheme. The course of treatment is 12 injections of 250-500 mg in combination with etiotropic therapy. The total dose of 3-6 g. Repeated courses are carried out as necessary.
With chlamydial infection, treatment is carried out according to the basic scheme. The course of treatment is 10 injections of 250 mg. The total dose is 2.5 g. The second course is after 10-14 days. It is advisable to combine cycloferon with antibiotics.
In acute viral hepatitis A, B, C, D and mixed forms, the drug is administered according to the basic scheme of 10 injections of 500 mg. The total dose is 5 g. In a protracted course, a second course is carried out after 10-14 days.
In chronic viral hepatitis B, C, D and mixed forms, the drug is administered according to the basic scheme of 10 injections of 500 mg, then according to the maintenance scheme 3 times a week. within 3 months as part of complex therapy. It is recommended in combination with interferons and chemotherapy. The course is repeated after 10-14 days.
For HIV infection (stage 2A-2B), the drug is prescribed according to the basic scheme of 10 injections of 500 mg and then according to the maintenance scheme once every three days for 2.5 months. The course is repeated after 10 days.
In immunodeficiency conditions, the course of treatment consists of 10 IM injections according to the basic scheme in a single dose of 250 mg. The total dose of 2.5 g. A second course is carried out after 6-12 months.
For rheumatic and systemic diseases of the connective tissue, 4 courses of 5 injections are prescribed according to the basic scheme, 250 mg each with an interval of 10-14 days. The doctor determines the need for a second course individually.
In case of degenerative joint diseases, 2 courses of 5 injections of 250 mg each are prescribed with a break of 10-14 days according to the basic scheme. The doctor determines the need for a second course individually.
Children Cycloferon is prescribed IM or IV once a day. The daily therapeutic dose is 6-10 mg / kg body weight.
In acute viral hepatitis A, B, C, D and mixed forms, 15 injections of the drug are performed according to the basic scheme. With a prolonged course of infection, the course is repeated after 10-14 days.
In chronic viral hepatitis B, C, D, the drug is administered according to the basic scheme of 10 injections and then according to the maintenance scheme 3 times a week for 3 months as part of complex therapy. Recommended use in combination with interferons and chemotherapy.
In case of HIV infection (stages 2A-2B), a course of 10 injections is prescribed according to the basic scheme and then according to the maintenance scheme once every 3 days for 3 months. A second course is carried out after 10 days.
For herpetic infections, a course of 10 injections is carried out according to the basic scheme. While maintaining the replicative activity of the virus, the treatment is continued according to the maintenance schedule with the introduction of the drug 1 time in 3 days for 4 weeks.
Side effects
Allergic reactions.
Drug Interactions
Cycloferon is compatible with all drugs used in the treatment of these diseases (interferons, chemotherapeutic, symptomatic drugs, etc.). Enhances the action of interferons and nucleoside analogues. Reduces the side effects of chemotherapy, interferon therapy.
Storage Conditions
Store in a dry, dark place at 0 ° to 25 ° C. Freezing the injection solution during transportation (at negative temperature) does not change the properties. Thawed at room temperature, the drug retains its biological and physico-chemical properties.
When changing the color of the solution and forming a precipitate, the use of the drug is unacceptable.
Expiration
3 years.
Terms leave through pharmacies
In retseptu
Dosage form
solution for injection and infusions
Polysan NTFF OOO, Russia
