Description
Release form
Tablets.
Packing
10 pcs.
Pharmacological action
Meloxicam is a non-steroidal anti-inflammatory drug.
It has anti-inflammatory, analgesic, antipyretic effects.
Indications
Rheumatoid arthritis osteoarthrosis ankylosing spondylitis (ankylosing spondylitis) and other inflammatory and degenerative joint diseases accompanied by pain. Designed for symptomatic therapy, reducing pain and inflammation at the time of use does not affect the progression of the disease.
Contraindications
Hypersensitivity (including other NSAIDs), the ² Ñaspirin ² Ñ triad (a combination of bronchial asthma, recurrent nasal polyposis and paranasal sinuses and intolerance of the acetylsalicylic acid and duodenal ulcer and pyrezole ulcers) gastrointestinal, cerebrovascular or other bleeding, severe heart failure, severe liver failure, severe renal failure (if hemodialysis is not performed), pregnancy, breastfeeding, age up to 15 years.
Special instructions
Caution should be exercised when using the drug in patients with a history of gastric or duodenal ulcer, as well as in patients undergoing anticoagulant therapy. Such patients have an increased risk of erosive and ulcerative diseases of the gastrointestinal tract.
Caution should be exercised and renal function indicators monitored when using the drug in elderly patients, patients with chronic heart failure with symptoms of insufficient circulation, in patients with cirrhosis of the liver, as well as in patients with hypovolemia as a result of surgical interventions.
In patients with renal failure, if creatinine clearance is more than 25 ml / min, dosage adjustment is not required.
In patients on dialysis, the dosage of the drug should not exceed 7.5 mg / day.
Patients taking both diuretics and meloxicam should take enough fluids.
If an allergic reaction occurs during treatment (itching, skin rash, urticaria, photosensitivity), you must stop taking the drug and consult a doctor.
Composition
1 tablet contains meloxicam 15 mg.
Dosing and Administration
Meloxicam is taken orally, with meals, without chewing, at a dose of 7.5-15 mg once a day.
The dose is selected individually, it is necessary to use the lowest effective dose for a minimum period of time.
Side effects
From the digestive tract:> 1% – dyspepsia, nausea, vomiting, abdominal pain, constipation / diarrhea, flatulence 0.1-1% – stomatitis, transient changes in liver function indicators (increased levels of transaminases or bilirubin), belching, esophagitis, stomach ulcer and duodenal ulcer, latent or macroscopically visible gastrointestinal bleeding
From the nervous system and sensory organs:> 1% – headache, dizziness 0.1-1% – vertigo, drowsiness, tinnitus
From the cardiovascular system and blood (hematopoiesis , hemostasis):> 1% – edema, anemia 0.1-1% – increase Blood pressure, palpitations, flushing, changes in the hemogram, including a change in the number of individual types of white blood cells, leukopenia, thrombocytopenia.
From the respiratory system: exacerbation of bronchial asthma, cough.
From the genitourinary system: 0, 1-1% – change in renal function (increase in creatinine and / or blood urea)
From the skin:> 1% – skin rash, itching 0.1-1% – urticaria
Allergic reactions:
Other:
Drug interaction
When used simultaneously with other non-steroidal anti-inflammatory drugs (as well as with acetylsalicylic acid), the risk of erosive and ulcerative lesions and bleeding of the gastrointestinal tract
is increased If it is used with antihypertensive drugs
simultaneous use with lithium preparations, it is possible to develop cumulation of lithium and increase its toxic effect (it is recommended to control centration of lithium in the blood)
When applied simultaneously with methotrexate amplified side effects of the latter on the hematopoietic system (risk of anemia and leukopenia, periodic monitoring of a general blood test is indicated)
With simultaneous use with diuretics and with cyclosporine, the risk of developing renal failure
increases With simultaneous use with intrauterine contraceptives, the effectiveness of the latter
may decrease When used with anticoagulants (heparin, ticlopidine, warfarin), as well with thrombolytic drugs (streptokinase, fibrinolysin), the risk of bleeding increases (periodic monitoring is necessary. atelier of blood coagulation)
With simultaneous use with colestiramine, as a result of the binding of meloxicam, its excretion through the gastrointestinal tract is enhanced.
Overdose
Symptoms:
impaired consciousness, nausea, vomiting, epigastric pain, gastrointestinal bleeding, acute renal failure, liver failure, respiratory arrest, asystole.
Treatment:
there is no specific antidote in case of drug overdose gastric lavage, activated charcoal intake (within the next hour), symptomatic therapy. Colestyramine accelerates the elimination of the drug from the body. Forced diuresis, alkalization of urine, hemodialysis are ineffective due to the high connection of the drug with blood proteins.
Storage Conditions
In a dark place at a temperature not exceeding 20 ° C.
Expiration
2 years.
active substance
Meloxicam
Terms leave through pharmacies
In retseptu
Vertex, Russia