Description
Pharmacological action
The combination of praziquantel and pyrantel pamoate, which are part of the drug, provides a wide range of its anthelmintic action on round and ribbon helminths parasitizing in the gastrointestinal tract in dogs and cats, including Tohosara sannis, Tohosara mistax, Toxascaris leonina, Uncinaria stenocephala, Trichuris vulpis, Ancylostoma caninum granulococulus, multichococulus, multichococulus, multichoculus, multichococcus Mesocestoides lineatus, Dipylidium caninum, Diphyllobotrium latum, Multiceps multiceps.
Pyrantel pamoate is a compound of the pyrimidine group that is active against sexually and immature nematodes, its mechanism of action is based on the blockade of transmission of nerve impulses in the neuromuscular synapses by depolarization of the membranes of muscle cells, which causes paralysis of the muscular system of nematodes, the pyrantel is poorly absorbed, which ensures its prolonged effect on helminths in the intestine is excreted from the body mainly unchanged (93%) with feces.
Praziquantel is a compound of the pyrazinisoquinoline group that is active against sexually and immature cestodes its mechanism of action is based on the induction of tegument breakdown and inhibition of fumarate reductase, persistent depolarization of the helminth muscle cells, impaired energy metabolism, which causes paralysis and death of the cestode and facilitates their intestinal elimination tract. Praziquantel is rapidly absorbed in the gastrointestinal tract, reaching a maximum concentration in plasma after 1 – 3 hours, distributed in the organs and tissues of the animal, binds to serum blood proteins (70 – 80%), is partially metabolized in the liver, and is re-secreted into the intestines, excreted mainly in the urine (up to 80%) within 24 hours.
Glistogon suspension, according to its degree of exposure to the body, belongs to “low-hazard substances” (hazard class 4 according to GOST 12.1.007-76) in the recommended doses it does not have immunotoxic, embryotoxic and teratogenic effects. Well tolerated by dogs and cats of different breeds and ages.
Indications
anthelmintic suspension designate an adult cats and dogs small breeds, as well as puppies and kittens from 3 weeks of age with a curative and prophylactic intestinal forms nematodosiss (toxocariasis, toksaskaridoz, untsinarioz, ancylostomiasis, trichuriasis) cestodosis (teniidoze, dipilidioz , echinococcosis, diphyllobothriasis, mesocestoidosis) and associative nematode-cestodose invasions.
Contraindications
Contraindication to use is the increased individual sensitivity of the animal to the components of the drug, including a history of it. You should not use the drug exhausted, sick with infectious diseases and recovering animals, as well as puppies and kittens younger than 3 weeks of age.
Composition
Glistogon suspension in 1 ml contains pyrantel pamoate – 50 mg and praziquantel – 10 mg as active ingredients, as well as excipients: sorbic acid – 10 mg, bentonite – 10 mg, xanthan gum – 0.3 mg, syrup creamy – 465 mg and distilled water – up to 1 ml.
Dosage and administration
The drug is administered orally individually, in the morning feeding with a small amount of feed or forcefully introduced to the root of the tongue using a syringe dispenser in a dose of 1 ml per 2 kg of animal weight.
For therapeutic purposes, deworming of animals is carried out according to indications. With a strong degree of invasion, treatment is recommended to be repeated after 10 to 14 days.
For prophylactic purposes, deworming of animals is carried out once every 3 months at a therapeutic dose, and also before each vaccination for 10-14 days.
Shake the vial carefully before each use.
Side effects
Side effects and complications when using the drug in accordance with this instruction, as a rule, are not observed. In some animals, violations of the gastrointestinal tract and increased salivation are possible, which disappear spontaneously and do not require the use of drugs.
With increased individual sensitivity to the components of the drug and the appearance of allergic reactions, its use is discontinued and antihistamines and symptomatic therapy are prescribed to the animal.
Drug Interactions
The drug should not be used concomitantly with anthelmintic agents containing piperazine and drugs that inhibit cholinesterase.
Overdose of
In case of drug overdose, an animal may experience depression, refusal to feed, excessive salivation, upset gastrointestinal tract. In these cases, enterosorbents and symptomatic therapy are used.
Dosage
oral suspension
