Description
Pharmacological action
Dirofen-paste 20 and 60 refers to combined anthelmintic drugs. Thanks to praziquantel and pyrantel, which is part of the preparation, it has a wide spectrum of anthelmintic action on sexually mature and larval stages of development of round and ribbon helminths, which are parasitic in dogs and cats (Tohosara sannis, Tohosara mistax, Toxascaris leonina, Uncinaria stenocephphoma, Uninaria stenichurisphalomaphalaisphaloma phalaisphaloma lephinisphisis, Uncinaria stenocephula Echinococcus granulosus, Alveococcus multilocularis, Mesocestoides lineatus, Dipylidium caninum, Diphyllobotrium latum, Multiceps multiceps), in ferrets (Toxoscaris leonina, Toxocara cati and Ancylastoma sp. , Rodentolepis straminea, Hymenolepis nana, Hymenolepis diminuta).
The mechanism of action of praziquantel and pyrantel pamoate, which are part of the drug, based on the inhibition of fumarate reductase, persistent depolarization of the helminth muscle cells, impaired energy metabolism, which causes paralysis and death of helminths and contributes to their elimination from the gastrointestinal tract.
When administered orally, praziquantel is rapidly absorbed in the gastrointestinal tract, reaching a maximum plasma concentration after 1 to 3 hours, and is distributed in the animal’s organs and tissues, excreted mainly in the urine (up to 80%) within 24 hours. Pyrantel pamoate is poorly absorbed, which ensures its prolonged effect on helminths in the intestine, is excreted from the body mainly in unchanged form with feces (93%).
Dirofen paste 20 and 60 in terms of exposure to the body refers to low-hazard substances (hazard class 4 according to GOST 12.1.007-76), in recommended doses it does not have embryotoxic, teratogenic and sensitizing effects. Well tolerated by dogs and cats of different breeds and ages, ferrets and rodents.
Indications
Dirofen-paste is prescribed to dogs, cats, kittens, puppies, decorative rodents and ferrets with prophylactic and therapeutic purposes for nematodoses (toxocariasis, toxoscaridosis, uncinariosis, tricycosis, tencycidiosis diozidoziosis, tencyloidiosis, and tendenosis), ) and mixed nematode-cestodose invasions.
Contraindications
Contraindication to the use of the drug is individual intolerance to the components of the drug (including a history).
Dirofen-paste 20 and 60 should not be used in emaciated, sick with infectious diseases and recovering animals.
Composition
Pyrantela pamoate – 15 mg / ml, praziquantel – 5 mg / ml, excipients up to 1 ml.
active substance
pyrantel, praziquantel
