Description
Pharmacological action of
Dirofen suspension is a combination anthelmintic drug. It has a wide spectrum of anthelmintic action on the mature and larval stages of development of round and ribbon helminths, which parasitize dogs, cats and ferrets (Tohosara sannis, Tohosara mystax, Toxascaris leonina, Taenia solium, Uncinaria stenocephala, Trichuris vulpis, Ancylostoma caninum, Echinococcus granulosus, Alveococcus multilocularis, Mesocestoides lineatus, Dipylidium caniniforum syrpida multiforum multiceum Hymenolepis nana, Hymenolepis diminuta). The mechanism of action of praziquantel and pyrantel pamoate, which are part of the drug, is based on the inhibition of fumarate reductase, persistent depolarization of the helminth muscle cells, impaired energy metabolism, which causes paralysis and death of helminths and contributes to their elimination from the gastrointestinal tract. When administered orally, praziquantel is rapidly absorbed in the gastrointestinal tract, reaching a maximum concentration in blood plasma after 1-3 hours, and distributed in the organs and tissues of the animal is excreted from the body mainly with urine (up to 80%) within 24 hours. Pyrantel pamoate is poorly absorbed, which ensures its prolonged effect on helminths in the intestine, is excreted from the body mainly in unchanged form with feces (93%). Dirofen suspension, according to the degree of exposure to the body, is a low-hazard substance (hazard class 4 according to GOST 12.1.007-76), at the recommended doses it does not have an embryotoxic, teratogenic and sensitizing effect. Well tolerated by dogs and cats of different breeds and ages, ferrets and decorative rodents.
Indications
Dirofen suspension 60 is prescribed for adult dogs for prophylactic and therapeutic purposes in case of nematodoses (toxocariasis, toxoscaridosis, uncinariosis, trichocephalosis, hookworm infection, cystodoses, tenoridosis, diphylidiosis, echocodiosis, echinoderiasis, echinoderiasis, echinosis)
Contraindications
Contraindication to use is individual intolerance to the components of the drug (including a history). Dirofen suspension should not be used in malnourished patients with infectious diseases and recovering animals, nor should females in the first half of pregnancy, puppies, kittens, rodents and ferrets under 3 weeks of age. If necessary, pregnant women are prescribed the drug 3 weeks before the expected birth with caution, under the supervision of a veterinarian, and nursing females 2-3 weeks after the birth.
Special instructions
Dirofen suspension should not be used simultaneously with piperazine and cholinesterase inhibitors. The drug is not intended for use by productive animals.
Composition
Drug Dirofen suspension 60 (for adult dogs), contains in 1 ml as active ingredients: pyrantela pamoate – 45 mg and praziquantel – 15 mg, as well as excipients: pumpkin oil, tween-80, aspasvit C 200, sodium benzoate, Na-carboxymethyl cellulose and purified water.
Side effects of
When using Dirofen suspension in accordance with this instruction, side effects and complications in animals are usually not observed. With increased individual sensitivity to the components of the drug and the appearance of allergic reactions, its use is stopped and antihistamines and symptomatic therapy are prescribed to the animal.
dosage form
oral suspension
