Description
Pharmacological action
Combined multivitamin. The effect of the combination is determined by the properties of the vitamins that make up its composition. Neurotropic vitamins of group B have a beneficial effect in inflammatory and degenerative diseases of the nervous system and musculoskeletal system.
Thiamine (Vitamin B1) is involved in nerve conduction.
Pyridoxine (Vitamin B6) has a vital effect on the metabolism of proteins, carbohydrates and fats, is necessary for normal blood formation, the functioning of the central and peripheral nervous system. It provides synaptic transmission, inhibition processes in the central nervous system, is involved in the transport of sphingosine, which is part of the nerve sheath, and is involved in the synthesis of catecholamines.
Cyanocobalamin (vitamin B12) is involved in the synthesis of nucleotides, is an important factor in the normal growth, hematopoiesis and development of epithelial cells, is necessary for folic acid metabolism and myelin synthesis.
Lidocaine has an anesthetic effect at the injection site, dilates blood vessels, promoting the absorption of vitamins. The local anesthetic effect of lidocaine is due to the blockade of potential-dependent Na + channels, which prevents the generation of impulses at the ends of sensory nerves and the conduct of pain impulses along nerve fibers.
Indications
In the complex treatment of the following neurological diseases:
trigeminal neuralgia, facial neuritis, pain caused by diseases of the spine (intercostal neuralgia, lumbar ischialgia, lumbar syndrome, cervical syndrome, cervicobrachial syndrome, radicular syndrome caused by degenerative changes in the spine) polyneuropathy of various etiologies (diabetic, alcoholic).
Contraindications
Severe and acute forms of decompensated heart failure pregnancy lactation (breastfeeding) children (due to lack of data) hypersensitivity to the components of the combination.
Precautions
Heart rhythm disturbances, severe arterial hypotension.
Recommendations for the use of
In case of severe pain, it is advisable to start the treatment with a / m injection (deep) of 2 ml daily for 5-10 days, with a further transition to either oral administration of this combination in fixed doses or to rarer injections (2-3 times / week. For 2-3 weeks) with the possible continuation of therapy with a dosage form for oral administration.
Special instructions
In case of accidental iv administration, the patient should be under the supervision of a doctor or should be hospitalized depending on the severity of the symptoms.
In case of an overdose, dizziness, nausea, vomiting, itching, urticaria, increased sweating, tachycardia are possible.
Composition
Solution for i / m administration from pinkish red to red, with a specific odor.
1 ml
pyridoxine hydrochloride 50 mg
thiamine hydrochloride 50 mg
cyanocobalamin 0.5 mg
lidocaine hydrochloride 10 mg Excipients:
benzyl alcohol, 20 mg sodium
r sodium phosphate-trifol 10 M solution – to pH 4.0-5.0,
water d / i – up to 1 ml.
Side effects
Possible: allergic reactions in the form of itching, urticaria, shortness of breath, Quincke’s edema, anaphylactic shock.
In some cases: sweating, tachycardia, acne.
Terms of delivery from
pharmacies Prescription
dosage
form injection solution
