Description
Pharmacological action
Semi-synthetic bioflavonoid (rutin derivative) of the benzopyran class, has P-vitamin activity, has venotonic, angioprotective, anti-inflammatory and anti-edematous effects, reduces capillary permeability and fragility.
Its pharmacodynamic properties are associated with the participation of troxerutin bioflavonoids in redox processes and inhibition of hyaluronidase. By inhibiting hyaluronidase, troxerutin stabilizes the hyaluronic acid of the cell membranes and reduces their permeability.
It has antioxidant activity, as a result of which it prevents the oxidation of ascorbic acid, adrenaline and lipids. Moreover, reduces the permeability and fragility of capillaries, prevents damage to the basement membrane of endothelial cells when exposed to various factors.
Troxerutin increases the density of the vascular wall, reduces the exudation of the liquid part of the plasma and the diapedesis of blood cells. Reduces exudative inflammation in the vascular wall, reducing platelet adhesion to its surface. It inhibits aggregation and increases the degree of deformation of red blood cells.
The use of troxerutin is possible, both in the initial and late stages of treatment of chronic venous insufficiency, it is possible to use as one of the components of complex treatment. Troxerutin reduces swelling and a feeling of heaviness in the legs, reduces the intensity of pain and cramps, improves trophic tissue.
Troxerutin relieves symptoms associated with hemorrhoids (pain, exudation, itching, bleeding).
Due to its effect on the permeability and resistance of capillary walls, troxerutin slows the progression of diabetic retinopathy. The effect of troxerutin on the rheological properties of blood helps prevent the development of retinal vascular microthrombosis.
Pharmacokinetics
Troxerutin is rapidly absorbed when taken orally. The maximum concentration of troxerutin in blood plasma (Cmax) is established on average 1.75 ± 0.46 hours after ingestion. Absorption is approximately 10-15%. The bioavailability of the drug increases with increasing dose.
The half-life (T1 / 2) is 6.77 ± 2.37 hours. The therapeutic concentration of the drug in plasma is maintained for 8 hours. 30 hours after taking troxerutin, a second maximum plasma concentration of the drug is observed due to enterohepatic recirculation.
Partially metabolized in the liver to form glucuronide and trihydroethyl quercetin. It is excreted mainly through the intestines (up to 65-70%), a smaller part (up to 25%) of the drug is excreted unchanged by the kidneys.
Indications
The drug Phlebopress ® 300 mg capsules is used as part of the complex therapy of these diseases:
chronic venous insufficiency
trophic disorders in chronic venous insufficiency and trophic ulcers
varicose veins
superficial thrombophlebitis, peripheral
syndrome post-thrombotic syndrome
post-traumatic pulmonary edema and hematoma tissue and hematoma removal of varicose veins of the lower extremities
hemorrhoids (to alleviate symptoms)
diabetic angiopathy, retinopathy.
Contraindications
hypersensitivity to troxerutin and other components of the drug
peptic ulcer of the stomach, duodenum, chronic gastritis in the exacerbation phase of
lactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome
pregnancy (I trimester)
period of breastfeeding
children’s age up to 18 years (experience with limited use).
Precautions:
Chronic renal failure (with prolonged use).
Special instructions
The experience with Phlebopress ® in children under the age of 18 is insufficient. In the treatment of superficial thrombophlebitis or deep vein thrombosis, the use of the drug does not exclude the need for the appointment of anti-inflammatory and antithrombotic agents.
Phlebopress ® is ineffective in edema caused by concomitant diseases of the liver, kidneys and heart.
With the independent use of the drug, the maximum dates and recommended doses should not be exceeded.
If during the period of use of the drug the severity of the symptoms of the disease does not decrease or the symptoms of the disease worsen, you should immediately consult a doctor.
Impact on the ability to drive vehicles, mechanisms
Taking Phlebopress ® does not affect motor and mental reactions, does not interfere with driving and other complex mechanisms.
Composition
Per 1 capsule:
Active ingredient:
troxerutin – 300.00 mg.
Excipients:
lactose monohydrate (milk sugar) – 39.50 mg
sodium carboxymethyl starch – 7.00 mg
magnesium stearate – 3.50 mg.
Dosage and Administration
Inside. Capsules should be swallowed whole during meals, with plenty of water.
At the initial stage of treatment, 1 capsule (300 mg) is prescribed 3 times a day. The effect usually develops within 2 weeks. Further, treatment is continued at the same dose or reduced to the average therapeutic dose – 1 capsule 2 times a day (600 mg), or suspended (while the effect achieved remains for at least 4 weeks). If necessary, the dose can be increased after consulting a doctor. The course of treatment averages 3-4 weeks.
For maintenance therapy, taking 1 capsule (300 mg) per day for 3-4 weeks is sufficient.
For diabetic retinopathy, Phlebopress ® is prescribed in 2 capsules (single dose 600 mg) 3 times a day (daily dose 1.8 g).
On average, the duration of a therapeutic course is 3-4 weeks.
The need for a longer treatment is determined after consultation with a doctor and individually.
Side effects
Troxerutin is very well tolerated, in rare cases mild adverse reactions occur.
Disorders of the immune system: hypersensitivity reactions.
Disorders of the nervous system: headache.
Disorders from the vessels: “flushing” of blood to the face.
Disorders of the gastrointestinal tract: nausea, vomiting, stomach pain, flatulence, diarrhea, erosive and ulcerative lesions of the gastrointestinal tract. Disorders from the skin and subcutaneous tissues: erythema, skin itching, skin rash.
If any of the side effects indicated in the instructions are aggravated or you notice any other side effects not listed in the instructions, inform your doctor!
Overdose
Symptoms. Troxerutin has a very low toxicity. In case of an overdose, the following symptoms may appear: agitation, nausea, headache, flushing of the face.
treatment. It is necessary to rinse the stomach, take activated charcoal (within an hour after ingestion). If necessary, carry out symptomatic and supportive treatment.
In case of overdose, consult a doctor immediately.
Storage conditions
At a temperature not exceeding 25 ° C.
Keep out of the reach of children.
Expiration
3 years.
Do not use after the expiration date.
Terms and conditions otpuska IZ drugstore
Without a prescription
capsule dosage form
