Description
Release form
Intramuscular solution.
Packing
10 ampoules.
Pharmacological action of
Mucosate has a chondroprotective, chondrostimulating, regenerative stimulating effect.
Chondroitin sodium sulfate is an acidic mucopolysaccharide from cartilage of trachea in cattle with an average molecular weight of 11,000 Daltons (11 kiloDaltons), a stimulator of repair of connective (including cartilage) tissue.
The drug has a chondroprotective, stimulating the regeneration of cartilage, anti-inflammatory effect. It participates in the construction of the main substance of cartilage and bone tissue, improves phosphorus-calcium metabolism in cartilage, inhibits enzymes that disrupt the structure and function of articular cartilage, and inhibits the degeneration of cartilage. It stimulates the synthesis of proteoglycans, normalizes the metabolism of hyaline cartilage, and promotes the regeneration of cartilage surfaces and the articular bag. Prevents compression of connective tissue, increases the production of synovial fluid and mobility of the affected joints, reduces concomitant inflammation, soreness, and helps reduce the need for NSAIDs. With degenerative changes in the cartilage tissue is a means of replacement therapy.
A positive effect is observed already 2-3 weeks after the start of the drug. The therapeutic effect persists for a long time (3-6 months) after the end of the course of treatment.
Pharmacokinetics
Chondroitin sodium sulfate is readily absorbed after i / m administration. After 30 minutes, it is detected in blood in significant concentrations. Cmax is reached after 1 h, then its content gradually decreases over 2 days.
Chondroitin sodium sulfate accumulates mainly in cartilage. The synovial membrane is not an obstacle to its penetration into the joint cavity. 15 minutes after the intramuscular injection of chondroitin, sodium sulfate is found in the synovial fluid, then it enters the articular cartilage, where its content reaches a maximum after 48 hours.
Indications
Degenerative-dystrophic diseases of the joints and spine: primary arthrosis, intervertebral osteochondrosis, osteoarthritis, osteoporosis, periodontopathy, bone fractures (to accelerate bone marrow formation).
Contraindications
Hypersensitivity, tendency to bleeding, thrombophlebitis.
Composition
Active ingredient: chondroitin sodium sulfate 100 mg
Excipients: benzyl alcohol – 9 mg, water d / and – up to 1 ml.
Dosage and administration
The drug Mucosate is administered in oil 1 ml every other day. With good tolerance, the dose is increased to 2 ml, starting with the fourth injection. The course of treatment is 25-30 injections. If necessary, repeated courses are possible after 6 months.
Side effects
Allergic reactions (pruritus, erythema, urticaria, dermatitis), hemorrhage at the injection site rarely – nausea, vomiting.
Drug Interactions
Mucosat should be prescribed with caution along with direct-acting anticoagulants. It is also possible to increase the effect of indirect anticoagulants, antiplatelet agents and fibrinolytics.
Storage conditions i
In a dark place at a temperature of 0 20 ° C.
Expiration
3 years.
Deystvuyuschee substances
chondroitin sulfate sulfate
Terms of sale from
pharmacies Prescription
dosage form
injection solution
Synthesis, Russian
