Description
Pharmacological action of
Dehinel Plus, due to its active ingredients, has antiparasitic activity against cestodes: Echinococcus granulosus, Echinococcus multilocularis, Mesocestoides lineatus, Diphyllobothpsiumumumumumumumumumumumumumumumumumumumumumumidumium latipidium latium multiply. and nematodes: Toxocara canis, Toxascaris leonina, Uncinaria spp., Ancylostoma spp., Trichuris vulpis. Febantel, moderately absorbed from the gastrointestinal tract, causes nematodes to inhibit tubulin protein synthesis and glucose uptake, while inhibiting fumarate reductase, an enzyme responsible for the energy exchange of helminths. Pyrantel embonate is very poorly absorbed when administered orally and therefore has its effect directly on the surface of the mucous membrane of the gastrointestinal tract of a sick dog. It blocks neuromuscular transmission of an impulse in nematodes and causes paralysis of the helminth muscles, so parasites are easily removed from the gastrointestinal tract of the host. Praziquantel is well absorbed in the gastrointestinal tract and has a detrimental effect on cestodes (tapeworms) by increasing the permeability of the parasite cell membranes for calcium ions and suppressing fumarate reductase, which causes a spastic contraction of the parasite’s muscles, which turns into paralysis. Praziquantel is excreted in the bile unchanged. Dehinel Plus, in terms of its effect on the body of warm-blooded animals, is a low-hazard substance and does not have a sensitizing and hepatotoxic effect in recommended doses.
Indications
Assign to dogs for prophylactic and therapeutic purposes in case of nematodoses (toxocariasis, toxascaridosis, uncinariosis, hookworm, trichocephalosis) and cestodoses (tenyidoses, dipylidiosis, echinococcosis, diphylosis and diphylosis).
Contraindications
Increased individual sensitivity to the components of the drug. The use of the drug is not allowed for puppies in the first three weeks of life and puppies in the first two thirds of the gestation period.
It is not allowed to prescribe Dehinel Plus simultaneously with piperazine derivatives, levamisole, organophosphorus compounds and other drugs with cholinergic action.
Composition
Anthelmintic drug for dogs Dehinel Plus (international nonproprietary name: febantel + pyrantel embonate + praziquantel) as active ingredients in one tablet contains: 525 mg of febantel, 504 mg of pyrantel embonate and 175 mg of praziquantel, and as auxiliary components – lactose monohydrate, corn starch, povidone K30, sodium lauryl sulfate, microcrystalline cellulose, colloidal silicon anhydride and magnesium stearate.
Dosage and Administration
Dehinel Plus is used individually for dogs by mouth, once in the morning, at the rate of 1 tablet per 35 kg of animal weight.
It is not required to use a fasting diet and laxatives before use. In cases of intense infection with helminths, animals are recommended to re-use the drug after 14 days in the same dose. For therapeutic purposes, animals are given the drug according to indications, and for preventive purposes, quarterly (1 time in 3 months) in a therapeutic dose.
Symptoms of overdose in dogs have not been identified.
Features of the drug during its first use have not been established.
Side effects
Side effects and complications when using Dehinel Plus in accordance with this instruction, as a rule, are not observed.
In sensitive animals, in rare cases, individual signs of intolerance to the components of the drug are possible. When allergic reactions occur, the use of Dehinel Plus is stopped and desensitizing therapy is carried out.
