Description
Release form
Solution for external and local use, 7.5%.
Pharmacological action
Pharmacotherapeutic group:
Antiseptic
ATX:
D.08.AG02 Povidone-iodine
Pharmacodynamics:
Antiseptic, which is a complex of iodine and povidone, effective at pH 2. The bactericidal effect is due to free active iodine, which is released from the povidone-iodine complex. Compared with alcohol-containing solutions of iodine, an aqueous solution of povidone-iodine has a significantly less irritating effect.
Free iodine as a strong oxidizing agent reacts at the molecular level with insoluble fatty acids and practically non-oxidizing SH- and OH-groups of amino acids in enzymes and the main structural components of bacteria, both gram-positive and gram-negative, mycobacteria, fungi, especially Candida genus , various viruses and some protozoa. However, for the complete inactivation of some viruses and bacterial spores, a sufficiently long period of exposure to the drug is necessary.
There are no known cases of the development of resistance in microorganisms with prolonged use of povidone iodine.
Pharmacokinetics:
After the use of povidone iodine, some absorption of iodine is possible, which must be taken into account depending on the place, amount and duration of the drug. If small amounts of the drug are applied to intact skin, then iodine absorption is negligible. An increase in absorption may result from prolonged use of drugs containing povidone-iodine on mucous membranes, extensive wounds and burns, and especially after rinsing cavities.
As a result, there is a temporary increase in iodine in the blood. In people with a healthy thyroid gland, a higher iodine content does not entail clinically significant changes in the state of the thyroid gland. In normal iodine metabolism, excess iodine is removed through the kidneys.
Indications
Post-traumatic and postoperative wounds of various locations, burns, trophic ulcers, pressure sores, diabetic foot.
Damage to the skin of various origins, maceration, abrasion, bruises. Infections of the skin of various etiologies, including infectious dermatitis and eczema. Treatment of mucous membranes and skin of the patient before and after surgery, biopsy, puncture, including the skin around the drainage, catheters and probes.
Hygienic treatment of the hands of medical personnel, processing of the hands of surgeons.
Infections of the oral mucosa and nasopharynx.
Infections of the mucous membrane of the birth canal in women. Conducting small gynecological operations (artificial termination of pregnancy, the introduction of an intrauterine device, coagulation of erosion and polyp).
Use during pregnancy and lactation
The drug is not recommended for use from the third month of pregnancy and during breastfeeding.
It is possible to use the solution in pregnant women up to the ninth week of pregnancy, when the expected benefit of treatment with the drug exceeds the possible risk of complications.
Special instructions
Avoid contact with undiluted preparation in the eyes.
Impact on the ability to drive transp. Wed and fur .:
Not detected.
Composition of
100 g of solution contain:
active ingredient:
povidone-iodine (with 10% active iodine content) 7.5 g of
excipients:
sodium dihydrogen phosphate dihydrate,
sodium lauromacrogol-400, sodium
sodium
, sodium
, srdlkd ,
purified water up to 100 g.
Dosage and Administration
Topically, topically.
The drug is used in the form of a 7.5% solution or in diluted form. For dilution of the drug, 0.9% sodium chloride solution, Ringer’s solution, phosphate buffered solution can be used.
Povidone-iodine is applied to the surface by lubrication using a swab dipped in solution, irrigation using a mechanical spray, and wipes soaked in the solution are left on the surface.
The drug in the form of a 7.5% solution is used for antiseptic treatment of shallow wounds, burns, damage to the skin: abrasions, bruises for treating the patient s skin and mucous membranes before and after surgery, biopsy or puncture, skin around drains, catheters and probes.
When treating the skin before surgery, it is necessary to use a solution, avoiding its accumulation under the patient, as this can cause skin irritation.
To treat the hands of surgical personnel, 5 ml of the drug in the form of a 7.5% solution is applied to the skin of the hands and treated for 2.5 minutes. The procedure is repeated twice. For hygienic treatment of hands, apply 3 ml to the skin and process them for 1 min. Then rinse thoroughly with water.
The drug in diluted form is used: – in a dilution of 1: 2 – 1:20 for washing deep wounds, bedsores, trophic ulcers, with intraoperative wound treatment
– in a dilution of 1:25 in preoperative preparation of patients: limb washing
– diluted 1: 100 with preoperative preparation of patients: body washing
– in the form of a 1% solution when diluted with phosphate buffered saline: applied to the mucous membrane of the eyes.
All solutions of the drug are used only freshly prepared.
Povidone-iodine solutions should be applied to the damaged surface until it is completely moistened.
Napkins impregnated with a solution of povidone iodine are applied to the wound sutures. The antiseptic film formed during drying of povidone iodine is easily washed off with water.
The use of povidone-iodine solutions should continue until the signs of infection disappear or until the apparent risk of infection disappears.
Povidone-iodine solutions do not irritate and do not slow wound healing even with prolonged use.
Side effects
Hypersensitivity reactions to the drug are possible: delayed-type allergic reactions (itching, redness of the skin, blisters) or immediate-type allergic reactions (anaphylactoid reactions).
Long-term use of the drug (more than 7-10 days) and application to large skin surfaces, extensive wounds due to absorption can cause iodism (metallic taste in the mouth, excessive salivation and lacrimation, swelling of the mucous membranes) and systemic reactions (metabolic acidosis, hyponatremia, impaired renal and thyroid function), when they occur, you should stop using the drug and consult a doctor.
Drug interaction
The drug is incompatible with alkaloids (celandine), tannic acid (tannin), salicylic acid, silver, bismuth, taurolidine and hydrogen peroxide salts.
In the presence of blood and pus, the drug binds to proteins and other organic compounds, as a result of which its bactericidal activity may decrease. In this case, it is recommended to increase the frequency / frequency of the drug.
The simultaneous use of povidone iodine and topical preparations containing enzymes can contribute to the oxidation and suppression of their enzymatic activity. Povidone iodine has a synergistic effect with lithium preparations, as a result of which, with their long-term combined use, reversible inhibition of thyroid function is possible. Therefore, patients constantly taking lithium preparations should avoid prolonged application of povidone iodine on large surfaces.
The drug can lead to false-positive results in some diagnostic tests: determination of hemoglobin or sugar in urine and stool, examination of thyroid function. An examination of the thyroid gland in this case should be carried out no earlier than 1-2 weeks after the end of treatment with povidone-iodine.
Overdose of
After extremely intense absorption of iodine over an extended period, symptoms of hyperthyroidism, such as tachycardia, agitation, trembling, and headache, may be noted.
Mild forms of hyperthyroidism sometimes do not require intervention, and severe forms may require thyrostatic therapy.
Storage conditions
Store at 2 to 25 ° C in a dark place.
Keep out of the reach and sight of children.
Expiration
5 years.
Active substance
Povidone-Iodine
Conditions of release from drugstores
Without a prescription
lekarstvennaja form
Solution to the local Application
For
For adults, For children as prescribed by a doctor, Pregnant as prescribed
Indications
Indications
inflammation in the oral cavity , Small skin lesions, Burns, Insect bites, Pressure ulcers, Trichomoniasis, Thrush, Wounds, Trophic ulcers, Periodontitis, Pyoderma, Stomatitis